Expression level of lipoprotein lipase and dystrophin genes predict survival in B-cell chronic lymphocytic leukemia
| Autor: | Poltaraus Ab, Yu Yu Lorie, Andrey Sudarikov, Ancha Baranova, Malakho Sg, B V Biderman, Nikitin Ea, M M Peklo, A.Y. Shevelev, B V Zingerman, Evgeny A. Moskalev, T N Vlasik, I A Vorob'ev, A I Vorobjev |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research CD19 Dystrophin medicine Leukemia B-Cell Humans Gene Aged Regulation of gene expression Aged 80 and over Lipoprotein lipase biology Hematology Middle Aged medicine.disease Prognosis Molecular biology Leukemia Lymphocytic Chronic B-Cell Gene Expression Regulation Neoplastic Leukemia Lipoprotein Lipase Real-time polymerase chain reaction Treatment Outcome Oncology Cohort biology.protein Cancer research Leukocytes Mononuclear Female |
| Zdroj: | Leukemialymphoma. 48(5) |
| ISSN: | 1042-8194 |
| Popis: | Mutational status of immunoglobulin variable region genes (VH-genes) is known as the strongest predictor of long term prognosis in B-CLL. However, applications in the routine clinical practice are time consuming, and therefore some other predictions are required. In this study, we have compared prognostic values of real time PCR quantification of the expression levels of four genes previously shown to be differentially expressed in V(H)-unmutated and mutated B-CLL subtypes: ZAP-70, ZBTB20, DMD and LPL. The study included 134 B-CLL patients. Expression levels of LPL and DMD genes were significantly correlated to mutational status, while expression levels of of ZAP-70 gene correlated only in CD19+ selected cases (N = 40). No correlation was observed for ZBTB20 gene. Expression levels of LPL and DMD predicted overall survival in the entire cohort of patients. Prognostic values of LPL gene expression levels were significant even for CLL patients with stage A. Quantitative RT-PCR assays for measuring LPL gene expression are robust enough to be introduced into routine clinical practice. |
| Databáze: | OpenAIRE |
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