Volumes of distribution
| Autor: | Pierre-Louis Toutain, Alain Bousquet-Mélou |
|---|---|
| Přispěvatelé: | Physiologie et Toxicologie Expérimentales, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
040301 veterinary sciences
Analytical chemistry Models Biological 030226 pharmacology & pharmacy Loading dose 0403 veterinary science 03 medical and health sciences 0302 clinical medicine MESH: Plasma Volume Models Distribution (pharmacology) Animals Tissue Distribution MESH: Animals Plasma Volume MESH: Tissue Distribution Pharmacology Volume of distribution General Veterinary Chemistry Animal MESH: Veterinary Drugs MESH: Models Biological Veterinary Drugs 04 agricultural and veterinary sciences Plasma Biological MESH: Models Animal Models Animal Plasma concentration [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Initial volume of distribution |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics Journal of Veterinary Pharmacology and Therapeutics, Wiley-Blackwell, 2004, 27 (6), pp.441-53. ⟨10.1111/j.1365-2885.2004.00602.x⟩ |
| ISSN: | 0140-7783 1365-2885 |
| DOI: | 10.1111/j.1365-2885.2004.00602.x⟩ |
| Popis: | International audience; Volumes of distribution are proportionality constants between total amount of drug in the body and plasma concentrations. As snapshot plasma drug concentrations may be measured in different conditions (at equilibrium, under pseudo-equilibrium condition,...), several volumes of distribution have been defined. The two most relevant are the volume of distribution at equilibrium (V(ss)), and the volume of distribution during pseudo-equilibrium (V(area)). Volumes of distribution are used to compute a loading dose (V(ss)) or the residual amount of drug in the body knowing plasma concentrations (V(area)). Volume of distribution may be interpreted in terms of drug distribution having recourse to physiological models involving drug binding to plasma and tissues. Volumes of distribution should be determined early in drug development programmes and those having a large volume of distribution may be selected to obtain a long terminal half-life even for drugs having a relatively high clearance. |
| Databáze: | OpenAIRE |
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