Association of syncytium-inducing phenotype of HIV-1 with CD4 cell count, viral load and sociodemographic characteristics
| Autor: | Hansjakob Furrer, Anna Christen, Thomas Wendland, Werner J. Pichler, Raffaele Malinverni, C. Minder, Roland Grunow, J. Von Overbeck |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Adolescent Lymphocyte Immunology HIV Infections Biology Giant Cells Peripheral blood mononuclear cell Cohort Studies Blood plasma medicine Humans Immunology and Allergy Aged Demography Univariate analysis Odds ratio Middle Aged Viral Load biology.organism_classification CD4 Lymphocyte Count Cross-Sectional Studies Phenotype Infectious Diseases medicine.anatomical_structure Lentivirus HIV-1 Female Viral disease Viral load |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-199811000-00016 |
| Popis: | Objectives: To study whether syncytium-inducing (Sl)/non-SI (NSI) phenotype of HIV-1 is associated with CD4+ lymphocyte count, plasma HIV RNA level, clinical stage and sociodemographic characteristics in antiretroviral-naive HIV-1-infected patients. Design: Cross-sectional analysis of single centre cohort study data. Methods: SI/NSI phenotype was determined using a cocultivation assay using patients' peripheral blood mononuclear cells and MT2 cells. Standard procedures were used for CD4+ cell counts and viral load measurements in plasma. Univariate and multivariate analyses of association of CD4+ cell counts, viral load, clinical stage, age, sex and mode of HIV transmission were performed. Results: In univariate analysis, Sl phenotype was significantly associated with lower CD4+ cell counts, higher HIV RNA plasma levels, symptomatic HIV disease, male sex and age 32-36 years (middle tercile). In multivariate analysis, only lower CD4+ cell counts were associated with Sl phenotype (odds ratio per increase of 100 x 10 6 /l, 0.54; 95% confidence interval, 0.38-0.78). Conclusions: HIV-1 SI phenotype was associated with lower CD4+ cell counts but not with higher plasma viral load, clinical stage or sociodemographic variables. |
| Databáze: | OpenAIRE |
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