Membrane phenotype of murine effector and suppressor T cells involved in delayed hypersensitivity and protective immunity to herpes simplex virus
| Autor: | A.A. Nash, P.G.H. Gell |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Isoantigens
T-Lymphocytes Immunology Population chemical and pharmacologic phenomena Biology medicine.disease_cause T-Lymphocytes Regulatory Virus law.invention Pathogenesis Mice Immune system law Immunity medicine Animals Hypersensitivity Delayed education Immunity Cellular education.field_of_study Cell Membrane Histocompatibility Antigens Class II Immunization Passive Herpes Simplex Complement System Proteins Phenotype Herpes simplex virus Delayed hypersensitivity Mice Inbred CBA Suppressor Female |
| Zdroj: | Cellular Immunology. 75:348-355 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/0008-8749(83)90332-5 |
| Popis: | The membrane phenotype of T cells involved in delayed hypersensitivity (DH), protective immunity, and suppression of delayed hypersensitivity to herpes simplex virus (HSV) has been determined. T cells from immune lymph nodes transferring DH and antiviral immunity to normal recipients were characterized as Lyt 1 + 2 − . There appeared to be no detectable antiviral role for Lyt 1 − 2 + cells in the transferred cell suspension. Splenic T cells suppressing the induction of DH to HSV were characterized as being both Lyt 1 + 2 − and Lyt 1 − 2 + 4 weeks after their induction. At earlier times, i.e., after 7 days, the suppression was mediated solely by the Lyt 1 + 2 − population. Thereafter, a progressive increase in the contribution of the Lyt 1 − 2 + suppressor was observed. Both the early and later phases of suppression were due to I-J positive cells. The nature of the two suppressor cell-types is discussed in relation to suppressor cell “cascades” and to the pathogenesis of herpes simplex virus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|