Behavioral correlates of activity of optogenetically identified locus coeruleus noradrenergic neurons in rats performing T-maze tasks
| Autor: | Antoine Harel, Anthony E. Pickering, Liyang Xiang, Susan J. Sara, HongYing Gao, Sidney I. Wiener |
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| Přispěvatelé: | Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Bristol [Bristol] |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adrenergic Neurons
Male 0301 basic medicine Time Factors Acceleration Action Potentials lcsh:Medicine Optogenetics Stimulus (physiology) Article Arousal 03 medical and health sciences 0302 clinical medicine Task Performance and Analysis Animals Premovement neuronal activity Rats Long-Evans Maze Learning lcsh:Science Multidisciplinary Behavior Animal [SCCO.NEUR]Cognitive science/Neuroscience lcsh:R Cognitive flexibility T-maze 030104 developmental biology Forebrain Linear Models Visual Perception Locus coeruleus Locus Coeruleus lcsh:Q Cues Psychology Neuroscience 030217 neurology & neurosurgery Anaesthesia Pain and Critical Care |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9, pp.1361. ⟨10.1038/s41598-018-37227-w⟩ Xiang, L, Harel, A, Gao, H, Pickering, A E, Sara, S J & Wiener, S I 2019, ' Behavioral correlates of activity of optogenetically identified locus coeruleus noradrenergic neurons in rats performing T-maze tasks ', Scientific Reports, vol. 9, no. 1, 1361 . https://doi.org/10.1038/s41598-018-37227-w Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) |
| ISSN: | 2045-2322 |
| Popis: | The nucleusLocus Coeruleus (LC) is the major source of forebrain norepinephrine. LC is implicated in arousal, response to novelty, and cognitive functions, including decision-making and behavioral flexibility. One hypothesis is that LC activation promotes rapid shifts in cortical attentional networks following changes in environmental contingencies. Recent recordings further suggest LC is critical for mobilizing resources to deal with challenging situations. In the present study optogenetically identified LC neuronal activity was recorded in rats in a self-paced T-maze. Rats were trained on visual discrimination; then place-reward contingencies were instated. In the session where the animal shifted tasks the first time, the LC firing rate after visual cue onset increased significantly, even as the animal adhered to the previous rule. Firing rate also increased prior to crossing photodetectors that controlled stimulus onset and offset, and this was positively correlated with accelerations, consistent with a role in mobilizing effort. The results contribute to the growing evidence that the noradrenergic LC is essential for behavioral adaptation by promoting cognitive flexibility and mobilizing effort in face of changing environmental contingencies. |
| Databáze: | OpenAIRE |
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