Susceptibility Alleles and Haplotypes of Human Leukocyte Antigen DRB1, DQA1, and DQB1 in Autoimmune Polyglandular Syndrome Type III in Japanese Population
Autor: | Yositaka Kumon, Koichi Asaba, Yukio Ikeda, Miki Mizobuchi, Tadashi Suehiro, Tosihiro Nakamura, Hiroshi Maruyama, Toshihiro Takao, Noriyasu Tanimoto, Mitsuru Nishiyama, Yasumasa Iwasaki, Kozo Hashimoto |
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Rok vydání: | 2005 |
Předmět: |
Adult
musculoskeletal diseases Pituitary disorder endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Hashimoto Disease Human leukocyte antigen HLA-DQ alpha-Chains Thyroiditis Endocrinology Gene Frequency Japan immune system diseases HLA-DQ Antigens medicine HLA-DQ beta-Chains Humans Genetic Predisposition to Disease Polyendocrinopathies Autoimmune skin and connective tissue diseases HLA-DRB1 Alleles Aged Type 1 diabetes business.industry Thyroid Haplotype nutritional and metabolic diseases HLA-DR Antigens Middle Aged medicine.disease Graves Disease medicine.anatomical_structure Haplotypes Pediatrics Perinatology and Child Health Immunology business HLA-DRB1 Chains |
Zdroj: | Hormone Research in Paediatrics. 64:253-260 |
ISSN: | 1663-2826 1663-2818 |
Popis: | Background: It has been reported that HLA class II haplotypes DRB1*0405-DQA1*0303-DQB1*0401 and DRB1*0901-DQA1*0302-DQB1*0303 are major susceptibility haplotypes for type 1 diabetes mellitus (DM) in Japanese population. However, little has been reported on the susceptibility HLA class II haplotypes in Japanese patients with autoimmune polyglandular syndrome type II and type III (APS III). Patients and Methods: HLA class II haplotypes of DRB1-DQA1-DQB1 in 31 patients with APS III, 14 patients with Hashimoto’s thyroiditis alone, and 15 patients with Graves’ disease alone were examined in Japanese population. APS III patients were divided into three groups (A, B, and C) depending on the combination of autoimmune endocrine diseases. Results: In 13 APS III patients with both Hashimoto’s thyroiditis and type 1 DM (group A), the haplotype frequencies of the HLA DRB1*0802-DQA1*0401-DQB1*0402 and DRB1*0901-DQA1*0302-DQB1*0303 were significantly higher than in the controls. In patients with Hashimoto’s thyroiditis alone, the haplotype frequency of DRB1*0901-DQA1*0302-DQB1*0303 was significantly higher than in controls, whereas the frequency of DRB1*0802-DQA1*0401-DQB1*0402 did not differ significantly from those in the controls. In 11 APS III patients with both Graves’ disease and type 1 DM (group B), the haplotype frequencies of HLA DRB1*0405-DQA1*0303-DQB1*0401 and DRB1*0802-DQA1*0301-DQB1*0302 were significantly higher than in controls. In patients with Graves’ disease alone, the haplotype frequency of DRB1*0803-DQA1*0103-DQB1*0601 were significantly higher than those in controls, suggesting that the susceptibility haplotypes for group B APS III differed from those for Graves’ disease alone. In 7 APS III patients with both autoimmune thyroid diseases and pituitary disorders (group C), the haplotype frequency of HLA DRB1*0405-DQA1*0303-DQB1*0401 was significantly higher than in controls. Conclusions: Susceptible HLA class II haplotypes of DRB1-DQA1-DQB1 for APS III differ between the Japanese and Caucasian populations. More interestingly, the susceptible HLA class II haplotypes differ among the three types of Japanese APS III and are not merely a combination of susceptibility haplotypes of each endocrine disease. |
Databáze: | OpenAIRE |
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