Characteristics of youth at high risk for bipolar disorder compared to youth with bipolar I or II disorder
Autor: | Patricia D. Walshaw, Boris Birmaher, Christopher D. Schneck, Marc J. Weintraub, David Axelson, Kiki D. Chang, David J. Miklowitz, Manpreet K. Singh |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Bipolar Disorder Adolescent Poison control Anxiety Medical and Health Sciences Article 03 medical and health sciences 0302 clinical medicine Clinical Research 2.3 Psychological Behavioral and Social Science Humans Medicine Bipolar disorder Aetiology Psychiatry Biological Psychiatry Pediatric Depressive Disorder Depressive Disorder Major Depression business.industry Psychology and Cognitive Sciences Not Otherwise Specified Major Serious Mental Illness medicine.disease Anxiety Disorders Brain Disorders 030227 psychiatry Psychiatry and Mental health Mental Health Mood Attention Deficit Disorder with Hyperactivity Conduct disorder Major depressive disorder social and economic factors medicine.symptom business Psychosocial 030217 neurology & neurosurgery |
Zdroj: | J Psychiatr Res |
ISSN: | 0022-3956 |
Popis: | Significant efforts have been undertaken to characterize the phenomenology of the high-risk period for bipolar disorder (BD) through the examination of youth at familial risk (i.e., having a first- or second-degree relative with BD) or clinical high risk for the disorder (i.e., youth with BD Not Otherwise Specified [NOS] or major depressive disorder [MDD]). However, little is known about the phenomenology of youth at both familial and clinical high risk for BD. In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n=145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disorder/conduct disorder. Mood symptom severity and psychosocial functioning were progressively more impaired consistent with diagnostic severity: BD I>BD II>BD-NOS>MDD. Nonetheless, HR youth exhibited significant depressive symptom severity compared to adolescents with BD I and overall impairment in psychosocial functioning. These results provide further support for the high rates of anxiety disorders and premorbid dysfunction in addition to active mood symptoms for youth at risk for BD, and suggest anxiety is an important phenological characteristics and treatment target of the high-risk period. |
Databáze: | OpenAIRE |
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