The union of Anti-CD34 antibody can improve the performance of drug-eluting stents
| Autor: | Zhengcai Zhang, Xing-Sheng Yang, Xi Wu, Shu-Zheng Lu, Zhanjiang Yu, Hua-Gang Zhu, Fang Ren, Li-Jie Zhang, Yongqiang Chen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Neointima
medicine.medical_specialty Time Factors Swine medicine.medical_treatment Antigens CD34 Coronary Angiography Prosthesis Design Antibodies Coronary Restenosis Restenosis In vivo Angioplasty medicine Animals Radiology Nuclear Medicine and imaging Angioplasty Balloon Coronary Cell Proliferation Sirolimus Neointimal hyperplasia Hyperplasia business.industry Cardiovascular Agents Drug-Eluting Stents General Medicine medicine.disease Coronary Vessels Surgery Coronary arteries medicine.anatomical_structure Metals Cardiovascular agent Microscopy Electron Scanning Swine Miniature Stents Cardiology and Cardiovascular Medicine Nuclear medicine business Tomography Optical Coherence medicine.drug |
| Zdroj: | Catheterization and Cardiovascular Interventions. 79:972-978 |
| ISSN: | 1522-1946 |
| DOI: | 10.1002/ccd.23186 |
| Popis: | Objectives The authors investigate whether the combination of anti-CD34 antibody with DES is win-win cooperation. Background DES may reduce the risk of restenosis compared to bare-metal stents (BMS), but they were found to inhibit the healing process of intima. Methods Fifteen BMS, 17 DES, and 16 combined anti-CD34 antibody and DES were randomly implanted in the coronary arteries of 22 minipigs. Ten minipigs were followed up to 2 weeks. The stenting coronary segments were examined by histological examination and scanning electron microscopy after in vivo coronary angiography and intracoronary optical coherence tomography (OCT) examinations. The other 12 minipigs were followed up to 3 months. Coronary angiography and intracoronary OCT examination were performed in vivo and histological examination was performed on the stenting coronary segments. Results After 2 weeks, the neointimal covering level of the DES was lower than that in BMS, but the covering level of the combined stents was even better than the BMS. After 3 months, neointimal hyperplasia was significant in the BMS, but not in the other two types of stents. The in-stent late lumen loss of the combined stents even showed a decreasing tendency when compared with the DES. Conclusion The combination of anti-CD34 antibody and DES can not only well offset the short-term inhibitory effect on re-endothelialization but also slightly enhance the long-term antiproliferative effect. |
| Databáze: | OpenAIRE |
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