Rôle de la pollution au cours des pneumopathies interstitielles diffuses
| Autor: | Olivia Freynet, Lucile Sesé, Yurdagul Uzunhan, Florence Jeny, Hilario Nunes, W. Khamis, Jean-François Bernaudin, Isabella Annesi-Maesano, Dominique Valeyre |
|---|---|
| Přispěvatelé: | Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pollution business.industry media_common.quotation_subject [SDV]Life Sciences [q-bio] Interstitial lung disease medicine.disease Systemic scleroderma complex mixtures 3. Good health 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine 030228 respiratory system 13. Climate action Rheumatoid arthritis Immunology medicine Respiratory function 030212 general & internal medicine Respiratory system business Hypersensitivity pneumonitis media_common |
| Zdroj: | Revue des Maladies Respiratoires Revue des Maladies Respiratoires, Elsevier Masson, 2020, 37, pp.389-398. ⟨10.1016/j.rmr.2020.02.015⟩ |
| ISSN: | 0761-8425 |
| DOI: | 10.1016/j.rmr.2020.02.015⟩ |
| Popis: | Few studies have examined the effects of air pollution in diffuse interstitial lung disease and they have focused on small numbers of patients. Most data are available in idiopathic pulmonary fibrosis and studies suggest that the level of exposure to pollutants may influence the development of acute exacerbations (ozone and NO2), their incidence (NO2), decline in respiratory function (PM10) and death (PM10 and PM2.5). Several studies show an increase in the incidence of rheumatoid arthritis in people living near busy roads. In systemic scleroderma, hypersensitivity pneumonitis and sarcoidosis although negative effects of pollution have been reported the data are insufficient to be conclusive. Nevertheless, the observed effects of air pollution are consistent with those described for other chronic respiratory diseases. Exposure to pollution induces oxidative stress, chronic inflammation and shortening of telomeres, which are all mechanisms described in fibrogenesis. New epidemiological studies are needed with individual measurements of exposure to outdoor and indoor pollution, as well as fundamental studies to clarify the effect of pollution on fibrogenesis. |
| Databáze: | OpenAIRE |
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