No association between rs6897932 in the gene encoding interleukin-7 receptor α and low-grade inflammation or self-reported health - results from the Danish Blood Donor Study
| Autor: | Erik Sørensen, Hans J. Hartling, Lise Wegner Thørner, Henrik Hjalgrim, Cecilie J. Sørensen, Kristoffer Sølvsten Burgdorf, Christian Erikstrup, Sebastian Kotzé, Ole Birger Pedersen, Mikkel Steen Petersen, Susanne Dam Nielsen, Andreas S. Rigas, Henrik Ullum |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Microbiology (medical) Mononucleosis Denmark Single-nucleotide polymorphism Inflammation Polymorphism Single Nucleotide Pathology and Forensic Medicine Interleukin-7 Receptor alpha Subunit Gene Frequency Quality of life Surveys and Questionnaires Humans Immunology and Allergy Medicine Infectious Mononucleosis Allele frequency Alleles biology business.industry Multiple sclerosis C-reactive protein General Medicine Middle Aged medicine.disease C-Reactive Protein Interleukin-7 receptor-α Immunology Quality of Life biology.protein Female Self Report medicine.symptom business |
| Zdroj: | Hartling, H J, Sørensen, C J, Rigas, A S, Burgdorf, K S, Nielsen, S D, Pedersen, O B, Petersen, M S, Sørensen, E, Kotzé, S, Thørner, L W, Hjalgrim, H, Erikstrup, C & Ullum, H 2014, ' No association between rs6897932 in the gene encoding interleukin-7 receptor α and low-grade inflammation or self-reported health-results from the Danish Blood Donor Study ', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 123, no. 2, pp. 169-174 . https://doi.org/10.1111/apm.12334 |
| ISSN: | 0903-4641 |
| DOI: | 10.1111/apm.12334 |
| Popis: | The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. Low-grade inflammation (LGI) and self-reported, health-related quality of life (HRQL) are often associated with chronic diseases and widely used in assessing and monitoring health status. The aim of the present study was to evaluate whether the T-allele in rs6897932 is associated with reduced risk of LGI (hsCRP 3-10 mg/L), history of infectious mononucleosis (IM), and HRQL in healthy individuals. A total of 17, 293 healthy Danish individuals from the Danish Blood Donor Study were included in the analyses. We tested rs6897932 as a predictor of LGI, self-reported IM, and HRQL in univariable and multivariable models stratified by sex. No associations between rs6897932 and LGI, self-reported IM or HRQL were found in men or women. This suggests that rs6897932 is not associated with general inflammation, and the reported associations between the T-allele in rs6897932 with several autoimmune diseases may be mediated through effects on a restricted part of the immune system. |
| Databáze: | OpenAIRE |
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