Benign Schwannoma With Perineurioma-Like Areas: A Clinicopathologic Study of 11 Cases
| Autor: | Dominic V. Spagnolo, Dmitry E. Matsko, Michal Michal, Ksenya V. Shelekhova, Andrey Yu Orlov, Dmitry V. Kazakov, Gaetano Magro |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Antigens CD34 Biology Schwannoma Nerve Sheath Neoplasms Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Perineurioma Claudin-1 medicine Humans Aged Mucin-1 S100 Proteins Membrane Proteins Anatomy Middle Aged medicine.disease Gene Expression Regulation Neoplastic External lamina 030104 developmental biology 030220 oncology & carcinogenesis Reticular connective tissue Ultrastructure Female Surgery Neurilemmoma Clear cell |
| Zdroj: | International Journal of Surgical Pathology. 14:320-325 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/1066896906293417 |
| Popis: | Eleven schwannomas are described. All tumors were well demarcated and surrounded by a true capsule or pseudocapsule and manifested Antoni A and Antoni B areas, Verocay bodies, and hyalinized vessels. In addition to typical schwannoma, there were clear cell areas composed of spindled cells arranged either in parallel sheets or in loops within the myxoid matrix, morphologically identical to retiform (reticular) perineurioma. The Schwann cells in the conventional schwannomatous areas displayed typical ultrastructural features. Those comprising the perineurioma-like areas revealed a primitive morphology. They were slender or polygonal and were devoid of an external lamina, pinocytic vesicles, or junctions. These findings suggest that the perineurioma-like areas consist of primitive or modified Schwann cells, or, alternatively, these perineurioma-like areas represent true, but incomplete perineurial differentiation within otherwise ordinary benign schwannomas. These neoplasms represent a morphologic variant of schwannoma having distinctive perineurial-like areas, a pattern which may elicit diagnostic difficulties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|