[Cytokine production of peripheral mononuclear cells in HD-mite-allergic rhinitis patients]
| Autor: | Kan Ishii, Kohji Asakura, Akikatsu Kataura |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Mites
Rhinitis Allergic Perennial biology business.industry medicine.medical_treatment Dust biology.organism_classification Lymphocyte Activation Peripheral blood mononuclear cell Peripheral Interferon-gamma Cytokine Otorhinolaryngology Immunology Mite Leukocytes Mononuclear Medicine Animals Humans Interleukin-4 Interleukin-5 business |
| Zdroj: | Nihon Jibiinkoka Gakkai kaiho. 102(1) |
| ISSN: | 0030-6622 |
| Popis: | To elucidate the role of cytokines in the pathogenesis of allergic rhinitis, the proliferative response and cytokine production of peripheral mononuclear cells (PMNC) following stimulation with mite-antigen were evaluated in HD-mite-allergic rhinitis patients (mite-allergy group), non-HD-mite pollinosis patients (non-mite-allergy group) and normal subjects (normal group). The proliferative response of PMNC to PHA stimulation was not different among the groups, whereas that to mite-antigen stimulation was significantly higher in the mite-allergy group than in the normal group. Production of both IL-4 and IL-5 from PMNC after stimulation with mite-antigen was significantly higher in the mite-allergy group than in the normal group. Production of IFN-gamma from PMNC after antigen stimulation was significantly increased in both the mite-allergy and normal groups. The ratio of IFN-gamma to IL-4 synthesis was significantly higher in the normal group than in the mite-allergy group. This study revealed cytokine synthesis from PMNC after the antigen-stimulation was predominantly Th2-cytokines in patients with HD-mite-allergic rhinitis. |
| Databáze: | OpenAIRE |
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