Ovarian function after cancer treatment in young women affected by Hodgkin disease (HD)
| Autor: | Di Naro Edoardo, Liso Vincenzo, Lavopa Cristina, Guarini Attilio, Loverro Giuseppe, Giacomantonio Loredana |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Anti-Mullerian Hormone
Time Factors endocrine system diseases medicine.medical_treatment Primary Ovarian Insufficiency Dexamethasone Basal (phylogenetics) Follicle-stimulating hormone Ovarian Follicle Follicular phase Antineoplastic Combined Chemotherapy Protocols Survivors Amenorrhea Ultrasonography Triptorelin Pamoate biology Cytarabine Anti-Müllerian hormone Hematology Combined Modality Therapy Hodgkin Disease female genital diseases and pregnancy complications Dacarbazine Vincristine Female Luteinizing hormone Infertility Female hormones hormone substitutes and hormone antagonists Infertility Adult endocrine system medicine.medical_specialty Adolescent Prednisolone Vinblastine Sensitivity and Specificity Bleomycin Predictive Value of Tests Internal medicine medicine Humans Inhibins Mechlorethamine Ovarian reserve Cyclophosphamide Glycoproteins Chemotherapy business.industry Ovary Luteinizing Hormone medicine.disease Testicular Hormones Endocrinology Doxorubicin Procarbazine biology.protein Prednisone Cisplatin Follicle Stimulating Hormone business |
| Zdroj: | Hematology (Amsterdam, Netherlands). 12(2) |
| ISSN: | 1607-8454 |
| Popis: | We have evaluated the best method to assess the ovarian reserve and the ovarian protective effect of GnRH-analog (GnRH-a), in 29 women with Hodgkin's disease (HD) treated with chemotherapy (CHT). The ovarian reserve was studied by measuring the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, antimullerian hormone (AMH) and the ultrasound antral follicular count (AFC). The patients were randomly treated with or without GnRH-a. At the time of study menstrual function was normal in 21 cases (72.4%), but absent in 8 (27.5%). Mean basal values of FSH, LH, AMH, inhibin B and AFC were normal in patients less than 30 years old and in the group treated four years or less before observation. AFC appeared to be the best marker of reduced ovarian reserve and a combination of AFC-AMH or inhibin B appeared the best predictor. In the GnRH-a group, no women had amenorrhoea, although ovarian reserve assessment was not significantly different from those who were not treated. The time-interval from CHT was the only significant predictor of ovarian function in GnRH-a treated patients. In conclusion, ovarian reserve evaluation, in young patients treated by CHT, can be performed by AFC. GnRH-a treatment does not have a protective effect, but could delay the development of ovarian failure. |
| Databáze: | OpenAIRE |
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