Peptide Solubility Limits: Backbone and Side-Chain Interactions
| Autor: | Rahul Sarma, Gillian C. Lynch, B. Montgomery Pettitt, Ka Yiu Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Peptide 010402 general chemistry 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound Materials Chemistry Side chain Physical and Theoretical Chemistry Solubility chemistry.chemical_classification Aqueous solution Extramural Hydrogen bond Hydrogen Bonding 0104 chemical sciences Surfaces Coatings and Films Amino acid Crystallography 030104 developmental biology Monomer chemistry Quantum Theory Peptides |
| Popis: | We calculate the solubility limit of pentapeptides in water by simulating the phase separation in an oversaturated aqueous solution. The solubility limit order followed by our model peptides (GGRGG > GGDGG > GGGGG > GGVGG > GGQGG > GGNGG > GGFGG) is found to be the same as that reported for amino acid monomers from experiment (R > D > G > V > Q > N > F). Investigation of dynamical properties of peptides shows that the higher the solubility of a peptide is, the lower the time spent by the peptide in the aggregated cluster is. We also demonstrate that fluctuations in conformation and hydration number of peptide in monomeric form are correlated with the solubility of the peptide. We considered energetic mechanisms and dynamical properties of interbackbone CO-CO and CO···HN interactions. Our results confirm that CO-CO interactions more than the interbackbone H-bonds are important in peptide self-assembly and association. Further, we find that the stability of H-bonded peptide pairs arises mainly from coexisting CO-CO and CO···HN interactions. |
| Databáze: | OpenAIRE |
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