Figures S1, S2, S3, S4 from Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Autor: Darrin D. Stuart, William R. Sellers, Savithri Ramurthy, Emma Lees, Michael P. Dillon, Nicholas Keen, Mallika Singh, Payman Amiri, Mohammad Hekmat-Nejad, Richard Zang, Valery Polyakov, Robert Aversa, Jacob R. Haling, John Tellew, Alice Rico, Gisele Nishiguchi, Lesley A. Mathews Griner, Joshua M. Korn, Fang Shen, Yingyun Wang, Stacy Rivera, Vesselina G. Cooke, Giordano Caponigro, Yun Feng, Yuji M. Mishina, Wenlin Shao
Rok vydání: 2023
Popis: Figure S1: pMEK and pERK suppression in KRAS mutant and BRAFV600E cells by dabrafenib or RAF709. Figure S2: pMEK and pERK suppression in NRAS mutant and BRAFV600E cells by dabrafenib or RAF709. Figure S3: Cell cycle and apoptotic effects of RAF709 in KRASmut cells. Figure S4: Antiproliferative activity of RAF709 in HPAFII cells.
Databáze: OpenAIRE