Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems

Autor: Kasim Ozluk, Naciye Isbil-Buyukcoskun, Betul Cam-Etoz
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., Çam, Betül Etöz, İşbil, Naciye Büyükcoşkun, Özlük, Kasım, AAH-1692-2021
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Central Nervous System
Atropine
Vasopressin
(Beta mercapto beta beta cyclopentamethylenepropionyl1
o me tyrosine2
arginine8)vasopressin
Unclassified drug
Blood pressure regulation
Physiology
Vasodilator Agents
Mecamylamine
Biochemistry
Rats
Sprague-Dawley
Nicotinic receptor
Adrenomedullin
Immunoreactivity
Adrenomedullin[22-52]
Heart Rate
Receptors
Muscarinic acetylcholine receptor
Mechanisms
Vasopressin derivative
General Pharmacology
Toxicology and Pharmaceutics
lcsh:QH301-705.5
Calcitonin gene related peptide receptor
lcsh:R5-920
Cholinergic stimulation
Arginine vasopressin receptor 1A
General Neuroscience
Muscarinic receptor
Brain
General Medicine
Receptor antagonist
Cholinergic Neurons
Receptor blocking
Peptide
Blood pressure
Female
Calcitonin gene related peptide receptor[8-37]
lcsh:Medicine (General)
Blood-pressure
Drug mechanism
medicine.drug
medicine.medical_specialty
Consciousness
Vasopressins
medicine.drug_class
Short Communication
Immunology
Research & experimental medicine
Biophysics
Calcitonin gene-related peptide
Article
Vasopressin v1 receptor
Adrenomedullin Receptors
Receptor Activity-Modifying Proteins
Calcitonin Receptor Like Receptor
Internal medicine
medicine
Animals
Animal experiment
Medicine
research & experimental
Biology
Life sciences & biomedicine - other topics
Cardiovascular response
Injections
Intraventricular
Nervous-system
Rattus
business.industry
Drug receptor binding
Antagonist
Cell Biology
Nonhuman
Acetylcholine
Rats
Calcitonin gene related peptide receptor antagonist
Endocrinology
lcsh:Biology (General)
Parameters
Rat
Involvement
business
Receptors
Calcitonin Gene-Related Peptide
Zdroj: Brazilian Journal of Medical and Biological Research v.45 n.3 2012
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 45, Iss 3, Pp 250-255 (2012)
Brazilian Journal of Medical and Biological Research, Volume: 45, Issue: 3, Pages: 250-255, Published: MAR 2012
Popis: Our objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V-1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 mu L) caused an increase in both blood pressure and HR (Delta MAP = 11.8 +/- 2.3 mmHg and Delta HR = 39.7 +/- 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP(8-37)) and ADM receptor antagonist (ADM(22-52)) blocked the effect of central ADM on blood pressure and HR. 3) The nicotinic receptor antagonist mecamylamine (25 mu g/10 mu L, icv) and the muscarinic receptor antagonist atropine (5 mu g/10 mu L, icv) prevented the stimulating effect of ADM on blood pressure. The effect of ADM on HR was blocked only by atropine (5 mu g/10 mu L, icv). 4) The V-1 receptor antagonist [beta-mercapto-beta-beta-cyclopentamethylenepropionyl(1), O-me-Tyr(2),Arg(8)]-vasopressin (V2255; 10 mu g/kg), that was applied intravenously, prevented the effect of ADM on blood pressure and HR. This is the first study reporting the role of specific ADM and CGRP receptors, especially the role of nicotinic and muscarinic central cholinergic receptors and the role of peripheral V-1 receptors in the increasing effects of icv ADM on blood pressure and HR.
Databáze: OpenAIRE
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