Treatment of primary rectal squamous cell carcinoma by primary chemoradiotherapy: Should surgery still be considered a standard of care?
| Autor: | James Clark, C. Lowdell, Ara Darzi, Paul Ziprin, Susan Cleator, Robert D. Goldin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Colorectal cancer Antineoplastic Combined Chemotherapy Protocols medicine Humans Basal cell carcinoma Radical surgery Aged Neoplasm Staging Rectal Neoplasms business.industry Cancer Middle Aged Rectal Squamous Cell Carcinoma medicine.disease Anus Combined Modality Therapy Magnetic Resonance Imaging Surgery stomatognathic diseases Treatment Outcome medicine.anatomical_structure Oncology Epidermoid carcinoma Positron-Emission Tomography Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Chemoradiotherapy |
| Zdroj: | European Journal of Cancer. 44:2340-2343 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2008.07.004 |
| Popis: | Rectal squamous cell carcinoma is a rare tumour accounting for only 0.25% of all rectal carcinomas, yet it carries a significant mortality and morbidity. Radical surgery has been advocated as the primary treatment modality with or without adjunctive therapies despite the proven benefits of primary chemoradiotherapy for squamous cell carcinoma (SCC) of the anus. This report describes 7 cases of rectal squamous cell carcinoma from a single institution over a four-year period, treated with primary chemoradiotherapy. All patients demonstrated significant tumour regression, and surgery to the primary tumour was avoided in all but one of these cases. Primary chemoradiotherapy can achieve excellent local control for rectal squamous cell carcinoma with surgery employed only for unresponsive or recurrent tumours. |
| Databáze: | OpenAIRE |
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