Relevance function of microRNA-708 in the pathogenesis of cancer
| Autor: | Junfa Yang, Tao Xu, Yu-ping Shang, Qiang Huang, Si-nan Sun, Chuan-pu Shen, Hong Zhou, Jia-Si Chen, Shuang Hu, Liang-yun Li, Jun Li |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Bladder cancer Colorectal cancer Cancer Cell Biology Biology medicine.disease 03 medical and health sciences Prostate cancer MicroRNAs 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Cell Line Tumor Neoplasms microRNA medicine Cancer research Biomarker (medicine) Humans Epigenetics Lung cancer |
| Zdroj: | Cellular signalling. 63 |
| ISSN: | 1873-3913 |
| Popis: | MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally responsible for regulating >70% of human genes. MicroRNA-708 (miR-708) is encoded in the intron 1 of the Odd Oz/ten-m homolog 4 (ODZ4) gene. Numerous researches have confirmed that the abnormal expressed miR-708 is involved in the regulation of multiple types of cancer. Notably, the expression level of miR-708 was higher in lung cancer, bladder cancer (BC) and colorectal cancer (CRC) cell lines while lower in hepatocellular carcinoma (HCC), prostate cancer (PC), gastric cancer (GC) and so on. This review provides a current view on the association between miR-708 and several cancers and focuses on the recent studies of miR-708 regulation, discussing its potential as an epigenetic biomarker and therapeutic target for these cancers. In particular, the regulated mechanisms and clinical application of miR-708 in these cancers are also discussed. |
| Databáze: | OpenAIRE |
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