Will genetic testing alter the management of disease caused by infectious agents? A cost-effectiveness analysis of gene-testing strategies for prevention of rheumatic Fever
| Autor: | Charles H. King, Diana F. Fischler, Richard Gerkin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Cost effectiveness Cost-Benefit Analysis Disease Life Expectancy Outcome Assessment Health Care medicine Humans Genetic Testing Antibiotic prophylaxis Intensive care medicine Genetic testing medicine.diagnostic_test business.industry Disease Management Streptococcus Pharyngitis Cost-effectiveness analysis Antibiotic Prophylaxis medicine.disease Surgery Quality-adjusted life year Infectious Diseases Treatment Outcome Life expectancy Rheumatic fever Rheumatic Fever business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 34(11) |
| ISSN: | 1537-6591 |
| Popis: | Cost-effectiveness analysis was done to evaluate the potential health and economic effects of a genetic screening program to identify individuals at risk for rheumatic fever (RF). The current RF prevention strategy was compared with a new, primary prevention strategy involving early genetic testing and intensive prophylaxis to prevent a first attack among individuals at high risk for RF. When analysis of a hypothetical 2000 birth cohort was done from a societal perspective, the prevention strategy involving genetic screening and prophylaxis for high-risk persons reduced the number of RF cases and increased life span at an estimated discounted cost of $7900 per quality-adjusted life-year gained. Genetic screening became the preferred (least expensive) strategy if the test specificity was/=98%, the annual cost of prophylaxis was$550, or the annual cost of caring for an individual with severe rheumatic heart disease increased to$32,000. When used with available antibiotic prophylaxis, genetic testing has the potential to provide a cost-effective strategy for the primary prevention of RF and its sequelae. |
| Databáze: | OpenAIRE |
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