Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities
| Autor: | Akber Idhayadhulla, Likai Xia, Young-Jung Wee, Sung Hong Kim, Yong Rok Lee, Chong-Soon Lee |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Magnetic Resonance Spectroscopy Antioxidant DPPH Stereochemistry medicine.medical_treatment Drug Evaluation Preclinical Mass spectrometry medicine.disease_cause Biochemistry Antioxidants Inhibitory Concentration 50 chemistry.chemical_compound Drug Discovery medicine Organic chemistry Molecular Biology Pyrans Molecular Structure Chemistry Organic Chemistry Carbon-13 NMR Bacterial strain Anti-Bacterial Agents Proton NMR Antibacterial activity |
| Zdroj: | Bioorganic Chemistry. 52:77-82 |
| ISSN: | 0045-2068 |
| DOI: | 10.1016/j.bioorg.2013.11.008 |
| Popis: | Novel and diverse mollugin analogues (1–12) were synthesized using PhB(OH)2/AcOH-mediated electrocyclization reaction as a key step. The newly synthesized compounds were screened for antioxidant and antibacterial activities. Compounds 1, 2, 5, 6, 8, and 10–12 showed high antioxidant activities in DPPH inhibition (IC50 = 0.52–1.11 μM) compared with BHT (IC50 = 9.67 μM). Compounds 3 exhibited potent antibacterial activity against Staphylococcus aureus (KCTC-1916) bacterial strain at 100 μg/mL. Structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR data and high-resolution mass spectrometry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect