Low-Molecular Weight Small Molecules Can Potently Bind RNA and Affect Oncogenic Pathways in Cells
| Autor: | Blessy M. Suresh, Yoshihiro Akahori, Amirhossein Taghavi, Gogce Crynen, Quentin M. R. Gibaut, Yue Li, Matthew D. Disney |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of the American Chemical Society. 144(45) |
| ISSN: | 1520-5126 |
| Popis: | RNA is challenging to target with bioactive small molecules, particularly those of low molecular weight that bind with sufficient affinity and specificity. In this report, we developed a platform to address this challenge, affording a novel bioactive interaction. An RNA-focused small-molecule fragment collection ( |
| Databáze: | OpenAIRE |
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