Mild metatropic dysplasia: emphasis on the magnetic resonance imaging of articular cartilage thickening
| Autor: | Hiromi Edo, Hiroshi Matsumoto, Soichiro Tamada, Taro Yamashita, Fumiko Hamabe, Hiroshi Shinmoto, Koji Sumi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Pathology medicine.medical_specialty Metatropic Dysplasia medicine.diagnostic_test business.industry Cartilage 030305 genetics & heredity Magnetic resonance imaging Articular cartilage Case Report General Medicine Short stature 03 medical and health sciences medicine.anatomical_structure Skeletal disorder medicine Thickening medicine.symptom business 030304 developmental biology |
| Zdroj: | BJR | Case Reports |
| ISSN: | 2055-7159 |
| Popis: | Metatropic dysplasia (MD) is a rare skeletal disorder characterized by short stature due to epiphyseal cartilage and growth plate abnormalities. The severity of MD varies from mild to lethal. This disorder is caused by mutations in the transient receptor potential vanilloid 4 (TRPV4) that encodes calcium-permeable, nonselective cation channels. A 33-year-old female presented at our hospital with a history of worsening knee pain diagnosed at the previous institution as a case of osteoarthritis. Radiographs of the knee showed epiphyseal irregularity without joint space narrowing. On MRI, fat-suppressed proton density-weighted imaging revealed thickened articular cartilage with a smooth surface and an abnormal signal intensity of the subchondral bone; T1 weighted imaging demonstrated irregularity of the epiphysis. These findings and the familial history (both her children had TRPV4 mutations) led to the suspicion that her condition could be due to mosaicism for TRPV4 mutation. To the best of our knowledge, this is the first report of MRI findings focusing on articular cartilage thickening in a patient with mild MD. Bone dysplasia including MD should be considered in young patients with articular cartilage thickening and subchondral bone irregularities on MRI. |
| Databáze: | OpenAIRE |
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