Expression and Effect of Adrenomedullin in Pheochromocytoma
| Autor: | Anli Tong, Xin-Rong Fan, Zheng-pei Zeng, Han-Zhong Li, Xin Zheng, Guo-Qiang Liu, Weigang Yan, Dong-Mei Liu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Adrenal Gland Neoplasms Pheochromocytoma Receptor Activity-Modifying Protein 2 Receptor Activity-Modifying Proteins General Biochemistry Genetics and Molecular Biology Adrenomedullin Paracrine signalling History and Philosophy of Science Internal medicine medicine Humans RNA Messenger Autocrine signalling Receptor neoplasms DNA Primers Base Sequence Chemistry General Neuroscience Calcitonin Receptor-Like Protein Intracellular Signaling Peptides and Proteins Membrane Proteins Middle Aged Receptors Calcitonin medicine.disease Endocrinology medicine.anatomical_structure nervous system RAMP2 Calcitonin Female Adrenal medulla hormones hormone substitutes and hormone antagonists |
| Zdroj: | Annals of the New York Academy of Sciences. 1073:270-276 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1353.030 |
| Popis: | This study investigates the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin receptor-like receptor (RAMP2/CRLR) mRNA in pheochromocytoma by reverse transcriptase polymerase chain reaction (RT-PCR) and its effect on the proliferation of pheochromocytoma cells by MTT. The mRNA expression of ADM and its receptor RAMP2/CRLR was present in normal adrenal medulla and pheochromocytoma tissues. The mRNA expression of ADM, RAMP2, and CRLR is markedly higher in pheochromocytomas than in normal medulla. ADM inhibits the proliferation of human pheochromocytoma cells and exerts a possible autocrine or paracrine effect in the adrenal. |
| Databáze: | OpenAIRE |
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