Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria
| Autor: | Megan Dowler, Gerald Voss, W. Ripley Ballou, Urszula Krzych, Christian F. Ockenhouse, Nadia Tornieporth, Joe Cohen, Denise McKinney, Martine Delchambre, Janet Wittes, Ted Hall, Kent E. Kester, D. Gray Heppner, Jolie Palensky |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Adolescent Plasmodium falciparum Protozoan Proteins Antibodies Protozoan Lymphocyte Activation law.invention Randomized controlled trial law parasitic diseases Malaria Vaccines medicine Immunology and Allergy Animals Humans Malaria Falciparum Vaccines Synthetic biology business.industry Immunogenicity RTS S Middle Aged medicine.disease biology.organism_classification Recombinant Proteins Clinical trial Circumsporozoite protein Infectious Diseases Immunization Immunology Female business Malaria |
| Zdroj: | The Journal of infectious diseases. 183(4) |
| ISSN: | 0022-1899 |
| Popis: | After initial successful evaluation of the circumsporozoite-based vaccine RTS,S/SBAS2, developed by SmithKline Beecham Biologicals with the Walter Reed Army Institute of Research, protective efficacy of several regimens against Plasmodium falciparum challenge was determined. A controlled phase 1/2a study evaluated 1 or 2 standard doses of RTS,S/SBAS2 in 2 groups whose members received open-label therapy and 3 immunizations in blinded groups who received standard, one-half, or one-fifth doses. RTS,S/SBAS2 was safe and immunogenic in all groups. Of the 41 vaccinees and 23 control subjects who underwent sporozoite challenge, malaria developed in 7 of 10 who received 1 dose, in 7 of 14 who received 2 doses, in 3 of 6 who received 3 standard doses, in 3 of 7 who received 3 one-half doses, in 3 of 4 who received 3 one-fifth doses, and in 22 of 23 control subjects. Overall protective efficacy of RTS,S/SBAS2 was 41% (95% confidence interval, 22%-56%; P=.0006). This and previous studies have shown that 2 or 3 doses of RTS,S/SBAS2 protect against challenge with P. falciparum sporozoites. |
| Databáze: | OpenAIRE |
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