Polymorphism of Oprm1 Gene and Its Association with Manifestations of N-(1-Phenethyl-4-Piperidyl)Propionanilide Intoxication in Rats
| Autor: | M. B. Ivanov, G. V. Nazarov, I. S. Berdinskikh, A. V. Babkin, A. S. Nikiforov, V. N. Bykov, O. V. Varlamova |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Genotype medicine.drug_class Receptors Opioid mu Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Opioid receptor Internal medicine medicine Animals Hypnotics and Sedatives Allele OPRM1 gene Alleles business.industry General Medicine Rats Endocrinology business Sleep 030217 neurology & neurosurgery Sleep duration |
| Zdroj: | Bulletin of experimental biology and medicine. 165(1) |
| ISSN: | 1573-8221 |
| Popis: | We studied association of Oprm1 gene polymorphisms with signs of N-(1-phenethyl-4-piperidyl)propionanilide intoxication in rats. It was found that the rate of intoxication in laboratory animals depends on genetic features. A polymorphic variant rs105312806 of Oprm1 gene can be a possible marker of animal sensitivity to opioid receptor agonists. This hypothesis was supported by differences in the rats of intoxication signs such as time to lateral posture and sleep duration in homozygous rats carrying different alleles. In rats with AA genotype, the time to lateral posture was shorter by 1.3 times and sleep duration was longer by 3.5 times than in carriers of GG genotype. |
| Databáze: | OpenAIRE |
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