Evaluation of Urinary 8-Hydroxydeoxy-Guanosine as a Novel Biomarker of Macrovascular Complications in Type 2 Diabetes
| Autor: | Takeshi Matsumura, Tomoko Matsuo, Takahumi Senokuchi, Eiichi Araki, Hideki Kishikawa, Shinsuke Kiritoshi, Takeshi Nishikawa, Nobuhiro Miyamura, Daisuke Kukidome, Michiharu Sakakida, Nakayasu Wake, Takayuki Sasahara, Kazuhiro Sonoda |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Carotid Artery Common Endocrinology Diabetes and Metabolism Urinary system medicine.medical_treatment Type 2 diabetes Gastroenterology Drug Administration Schedule chemistry.chemical_compound Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Humans Insulin Aged Advanced and Specialized Nursing Creatinine Diabetic Retinopathy Framingham Risk Score business.industry Deoxyguanosine Diabetic retinopathy Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 chemistry 8-Hydroxy-2'-Deoxyguanosine Biomarker (medicine) Female Tunica Intima Tunica Media business Biomarkers Diabetic Angiopathies |
| Zdroj: | Diabetes Care. 26:1507-1512 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.26.5.1507 |
| Popis: | OBJECTIVE—To evaluate urinary 8-hydroxydeoxyguanosine (8-OHdG) as a marker for the progression of diabetic macroangiopathic complications. RESEARCH DESIGN AND METHODS—The content of urinary 8-OHdG, common carotid intima-media thickness (IMT), the coronary heart disease (CHD) risk score, the severity of diabetic retinopathy, and urinary albumin excretion were examined in 96 patients with type 2 diabetes, including 32 patients who had been nominated for the Kumamoto Study [Shichiri M, et al. Diabetes Care 23 (Suppl 2):B21–B29, 2000]. In addition, the patients from the Kumamoto Study were further evaluated regarding the effect of intensive insulin therapy on urinary 8-OHdG excretion. RESULTS—The urinary 8-OHdG:creatinine ratio (U8-OHdG) was 2.5-fold higher in patients with increased HbA1c than in those with normal HbA1c (P < 0.05). In addition, U8-OHdG was 2.3-fold higher in patients with increased IMT (P < 0.005). A similar result was observed between U8-OHdG and CHD risk score (P < 0.01). U8-OHdG was significantly higher in patients with simple retinopathy (P < 0.05) and those with advanced retinopathy (P < 0.01) than in patients without retinopathy. Similarly, U8-OHdG was significantly higher in patients with albuminuria (P < 0.01). Furthermore, in the Kumamoto Study, U8-OHdG was significantly lower in the multiple insulin injection therapy group compared with the conventional insulin injection therapy group (P < 0.01). CONCLUSIONS—Hyperglycemia independently increases 8-OHdG in patients with type 2 diabetes. 8-OHdG is a useful biomarker of not only microvascular but also macrovascular complications in patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
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