Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
| Autor: | Won Seok Park, Oh Sang Kwon, Hyeon Gyeong Yoo, Kwang-Hyun Cho, In Gyu Kim, Hyoseung Shin, Satoshi Itami, Chong Hyun Won, Donghun Lee, Shigeki Inui, A-Ri Cho |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Biology urologic and male genital diseases Biochemistry Cell Line lcsh:Biochemistry Transforming Growth Factor beta1 Internal medicine medicine Animals lcsh:QD415-436 lcsh:QH301-705.5 Androgenetic alopecia Molecular Biology Research Articles chemistry.chemical_classification Reactive oxygen species integumentary system Dermis Hydrogen Peroxide General Medicine Transforming growth factor beta Transfection Hair follicle Androgen Acetylcysteine Rats Androgen receptor Dermal papillae medicine.anatomical_structure Endocrinology lcsh:Biology (General) chemistry Receptors Androgen Transforming growth factors Androgens biology.protein Dermal papilla Reactive Oxygen Species Hair Follicle Transforming growth factor |
| Zdroj: | BMB Reports BMB Reports, Vol 46, Iss 9, Pp 460-464 (2013) |
| ISSN: | 1976-6696 |
| DOI: | 10.5483/bmbrep.2013.46.9.228 |
| Popis: | The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-β1 secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels of androgen exposure were reported to increase reactive oxygen species (ROS) generation. In this study, rat vibrissae dermal papilla cells (DP-6) transfected with androgen receptor showed increased ROS production following androgen treatment. We confirmed that TGF-β1 secretion is increased by androgen treatment in DP-6, whereas androgeninducible TGF-β1 was significantly suppressed by the ROSscavenger, N-acetyl cysteine. Therefore, we suggest that induction of TGF-β1 by androgen is mediated by ROS in hair follicle DPCs. [BMB Reports 2013; 46(9): 460-464] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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