Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans
| Autor: | Line Thams, Mads S. Larsen, Peter Sieljacks, Britt Christensen, Kristian Vissing, Birgitte Nellemann |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Once weekly Physical Therapy Sports Therapy and Rehabilitation Hematocrit Placebo 03 medical and health sciences Young Adult 0302 clinical medicine Animal science Oxygen Consumption medicine Journal Article Aerobic exercise Humans Orthopedics and Sports Medicine Comparative Study Darbepoetin alfa Erythropoietin Exercise medicine.diagnostic_test business.industry VO2 max 030229 sport sciences General Medicine Oxygen uptake Randomized Controlled Trial Physical therapy Hematinics business 030217 neurology & neurosurgery medicine.drug Progressive overload |
| Zdroj: | Sieljacks, P, Thams, L, Nellemann, B, Larsen, M S, Vissing, K & Christensen, B 2016, ' Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans ', Journal of Strength and Conditioning Research, vol. 30, no. 8, pp. 2307-2317 . https://doi.org/10.1519/JSC.0000000000001314 |
| ISSN: | 1533-4287 |
| DOI: | 10.1519/JSC.0000000000001314 |
| Popis: | Sieljacks, P, Thams, L, Nellemann, B, Larsen, MS, Vissing, K, and Christensen, B. Comparative effects of aerobic training and erythropoietin on oxygen uptake in untrained humans. J Strength Cond Res 30(8): 2307-2317, 2016-The present study examines responses to 10 weeks of aerobic training and/or erythropoiesis-stimulating agent (ESA) treatment on maximal oxygen uptake (V[Combining Dot Above]O2max). Thirty-six healthy, untrained men were randomly assigned to sedentary-placebo (n = 9), sedentary-ESA (SE) (n = 9), training-placebo (TP) (n = 10), or training-ESA (TE) (n = 8). The participants were treated subcutaneously once weekly with ESA (darbepoietin-α, week 1-3; 40 μg and week 4-10; 20 μg) or a placebo for 10 weeks. The training consisted of supervised cycling 3 times per week for 1 hour at an average of 65% of maximal watt, with a progressive overload during the intervention period. V[Combining Dot Above]O2max, wattmax, and hematological values were measured throughout the study. In addition, the total training workload and estimated energy consumption were recorded after each training session. ESA treatment increased hemoglobin (∼11 and ∼14%, p < 0.001) and hematocrit (∼12 and ∼13%, p < 0.001) in the SE and TE groups, respectively. The relative (but not absolute) increases in V[Combining Dot Above]O2max were more pronounced (p < 0.01) in TE (27 ± 6%), compared with SE (15 ± 4%) but not TP (19 ± 4%), indicating that training is superior to ESA in stimulating V[Combining Dot Above]O2max in untrained men. The increased oxygen uptake in the TE group did not result in higher absolute training workloads than in the TP group. In untrained men, training exhibits a greater stimulus for improvements in V[Combining Dot Above]O2max than ESA treatment, without pronounced additive effects, which is supported by similar average training workloads and energy consumption in TP and TE. Thus, in untrained men, training alone seems sufficient to induce improvement in V[Combining Dot Above]O2max. |
| Databáze: | OpenAIRE |
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