Development and Function of Uterine Glands in Domestic Animals
| Autor: | Thomas E. Spencer, Andrew M. Kelleher, Frank F. Bartol |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Swine Placenta Uterus Biology Epithelium Andrology Endometrium 03 medical and health sciences Mammary Glands Animal stomatognathic system Pregnancy Morphogenesis Genetics medicine Animals Secretion Uterine lumen Sheep General Veterinary Ovary 0402 animal and dairy science Cell Differentiation 04 agricultural and veterinary sciences 040201 dairy & animal science Hormones Fertility 030104 developmental biology medicine.anatomical_structure Animals Domestic Pituitary Gland Female Animal Science and Zoology Uterine gland Function (biology) Biotechnology |
| Zdroj: | Annual Review of Animal Biosciences. 7:125-147 |
| ISSN: | 2165-8110 2165-8102 |
| DOI: | 10.1146/annurev-animal-020518-115321 |
| Popis: | All mammalian uteri contain glands that synthesize or transport and secrete substances into the uterine lumen. Uterine gland development, or adenogenesis, is uniquely a postnatal event in sheep and pigs and involves differentiation of glandular epithelium from luminal epithelium, followed by invagination and coiling morphogenesis throughout the stroma. Intrinsic transcription factors and extrinsic factors from the ovary and pituitary as well as the mammary gland (lactocrine) regulate uterine adenogenesis. Recurrent pregnancy loss is observed in the ovine uterine gland knockout sheep, providing unequivocal evidence that glands and their products are essential for fertility. Uterine gland hyperplasia and hypertrophy during pregnancy are controlled by sequential actions of hormones from the ovary and/or pituitary as well as the placenta. Gland-derived histotroph is transported by placental areolae for fetal growth. Increased knowledge of uterine gland biology is expected to improve pregnancy outcomes, as well as the health and productivity of mothers and their offspring. |
| Databáze: | OpenAIRE |
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