The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
Autor: | Serpil C. Erzurum, Maria Elisabeth Lopes Moreira, Woo-Jin Shin, Tian Xia, Ruth Cortado, Otto O. Yang, Jenny Y. Mei, Zilton Vasconcelos, Priya R. Soni, Trevon Fuller, Suzy A.A. Comhair, Sherin U. Devaskar, Deisy Contreras, Brenda Asilnejad, Suan-Sin Foo, Kyle L. Jung, Rashmi Rao, Tara Kerin, Debika Bhattacharya, Yvonne J. Bryson, Mary Catherine Cambou, Shangxin Yang, L. Caroline Gibson, Francisco Javier Ibarrondo, Shubhamoy Ghosh, Patrícia Brasil, Jessica Cranston, Thalia Mok, Vaithilingaraja Arumugaswami, Weiqiang Chen, Viviana M. Fajardo, Nicole H. Tobin, Carla Janzen, Grace M. Aldrovandi, Omai B. Garner, Younho Choi, Xin Wu, Jae U. Jung, Karin Nielsen-Saines |
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Rok vydání: | 2021 |
Předmět: |
Serum
Proteomics Medicine (General) COVID19 serum proteomics Reproductive health and childbirth Pregnancy Infant Mortality 2.1 Biological and endogenous factors Aetiology Lung Pediatric Infectious Diseases In utero Cord blood Cytokines Female pregnancy medicine.symptom COVID19-exposed infants IFNλ signaling prenatal SARS-CoV-2 infection Adult Pediatric Research Initiative Adolescent COVID-19-exposed infants Mothers Inflammation Article General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Vaccine Related Young Adult R5-920 Immune system Clinical Research Biodefense ESM1 medicine Humans Conditions Affecting the Embryonic and Fetal Periods mother-infant pairs Proteomic Profiling business.industry Prevention Inflammatory and immune system Infant Newborn Infant COVID-19 IFN-λ signaling Perinatal Period - Conditions Originating in Perinatal Period medicine.disease Newborn Emerging Infectious Diseases Good Health and Well Being Immunology business |
Zdroj: | Cell reports. Medicine, vol 2, iss 11 Cell Reports Medicine, Vol 2, Iss 11, Pp 100453-(2021) Cell Reports Medicine |
Popis: | While pregnancy increases the risk for severe COVID19, the clinical and immunological implications of COVID19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID19 show increased inflammation and unique IFNλ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, ESM1, and reducing BGN and CD209. Finally, COVID19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3 and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks. Graphical Abstract The study performed by Foo et al. unveils distinct immune alterations of mothers and infants induced by SARS-CoV-2 infection during pregnancy. These findings highlight the importance of long-term post-pregnancy clinical follow-up of mother-infant dyads to prevent potential unforeseen health conditions following prenatal SARS-CoV-2 infection. |
Databáze: | OpenAIRE |
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