The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2

Autor: Serpil C. Erzurum, Maria Elisabeth Lopes Moreira, Woo-Jin Shin, Tian Xia, Ruth Cortado, Otto O. Yang, Jenny Y. Mei, Zilton Vasconcelos, Priya R. Soni, Trevon Fuller, Suzy A.A. Comhair, Sherin U. Devaskar, Deisy Contreras, Brenda Asilnejad, Suan-Sin Foo, Kyle L. Jung, Rashmi Rao, Tara Kerin, Debika Bhattacharya, Yvonne J. Bryson, Mary Catherine Cambou, Shangxin Yang, L. Caroline Gibson, Francisco Javier Ibarrondo, Shubhamoy Ghosh, Patrícia Brasil, Jessica Cranston, Thalia Mok, Vaithilingaraja Arumugaswami, Weiqiang Chen, Viviana M. Fajardo, Nicole H. Tobin, Carla Janzen, Grace M. Aldrovandi, Omai B. Garner, Younho Choi, Xin Wu, Jae U. Jung, Karin Nielsen-Saines
Rok vydání: 2021
Předmět:
Serum
Proteomics
Medicine (General)
COVID19
serum proteomics
Reproductive health and childbirth
Pregnancy
Infant Mortality
2.1 Biological and endogenous factors
Aetiology
Lung
Pediatric
Infectious Diseases
In utero
Cord blood
Cytokines
Female
pregnancy
medicine.symptom
COVID19-exposed infants
IFNλ signaling
prenatal SARS-CoV-2 infection
Adult
Pediatric Research Initiative
Adolescent
COVID-19-exposed infants
Mothers
Inflammation
Article
General Biochemistry
Genetics and Molecular Biology
Proinflammatory cytokine
Vaccine Related
Young Adult
R5-920
Immune system
Clinical Research
Biodefense
ESM1
medicine
Humans
Conditions Affecting the Embryonic and Fetal Periods
mother-infant pairs
Proteomic Profiling
business.industry
Prevention
Inflammatory and immune system
Infant
Newborn
Infant
COVID-19
IFN-λ signaling
Perinatal Period - Conditions Originating in Perinatal Period
medicine.disease
Newborn
Emerging Infectious Diseases
Good Health and Well Being
Immunology
business
Zdroj: Cell reports. Medicine, vol 2, iss 11
Cell Reports Medicine, Vol 2, Iss 11, Pp 100453-(2021)
Cell Reports Medicine
Popis: While pregnancy increases the risk for severe COVID19, the clinical and immunological implications of COVID19 on maternal-fetal health remain unknown. Here, we present the clinical and immunological landscapes of 93 COVID19 mothers and 45 of their SARS-CoV-2-exposed infants through comprehensive serum proteomics profiling for >1400 cytokines of their peripheral and cord blood specimens. Prenatal SARS-CoV-2 infection triggers NF-κB-dependent proinflammatory immune activation. Pregnant women with severe COVID19 show increased inflammation and unique IFNλ antiviral signaling, with elevated levels of IFNL1 and IFNLR1. Furthermore, SARS-CoV-2 infection re-shapes maternal immunity at delivery altering the expression of pregnancy complication-associated cytokines, inducing MMP7, MDK, ESM1, and reducing BGN and CD209. Finally, COVID19-exposed infants exhibit induction of T cell-associated cytokines (IL33, NFATC3 and CCL21), while some undergo IL-1β/IL-18/CASP1 axis-driven neonatal respiratory distress despite birth at term. Our findings demonstrate COVID19-induced immune rewiring in both mothers and neonates, warranting long-term clinical follow-up to mitigate potential health risks.
Graphical Abstract
The study performed by Foo et al. unveils distinct immune alterations of mothers and infants induced by SARS-CoV-2 infection during pregnancy. These findings highlight the importance of long-term post-pregnancy clinical follow-up of mother-infant dyads to prevent potential unforeseen health conditions following prenatal SARS-CoV-2 infection.
Databáze: OpenAIRE
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