Additional Value of Early Repolarization Pattern in Prediction of Obstructive Coronary Artery Disease as Assessed by Coronary Angiography
| Autor: | Li-Juan Liu, Dongdan Zheng, Yun-Jiu Cheng, Wei-Yi Mei, Qing Xu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty China Early Repolarization Pattern Disease Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment Severity of Illness Index Sudden cardiac death Coronary artery disease 03 medical and health sciences Electrocardiography 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Retrospective Studies business.industry Incidence (epidemiology) Incidence Coronary Stenosis General Medicine Odds ratio Middle Aged medicine.disease Coronary Vessels medicine.anatomical_structure Death Sudden Cardiac Cardiology Population study Female Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | International heart journal. 60(2) |
| ISSN: | 1349-3299 |
| Popis: | Recent reports show that an early repolarization pattern (ERP) is associated with a higher incidence of sudden cardiac death in patients with obstructive coronary artery disease (CAD). Sporadic case studies have pointed out that ERP might be related to obstructive CAD.In consecutive patients who had undergone coronary angiography, we investigated the relationship between ERP and obstructive CAD by evaluating its association with coronary artery stenosis.The study population consisted of 3785 patients (59.9% men; mean age 63.1 years) with or without obstructive CAD. Adjusting for major cardiovascular risk factors, ERP was significantly associated with obstructive CAD (adjusted odds ratio (OR): 2.24 [95% CI 1.70-2.95]) with an incremental predictive value (ROC AUC 0.76 versus 0.71, P = 0.02; NRI 55.3%, P < 0.001; IDI = 0.05, P = 0.008), specifically in subjects with low risk and intermediate risk. ERP also significantly improved the predictive value for multi-vessel disease (AUC: 0.77 versus 0.72, P = 0.02 for two-vessel disease; 0.79 versus 0.73, P = 0.04 for three-vessel disease). ERP was consistently associated with stenoses of 3 main coronary arteries.ERP is associated with significant increased risk for obstructive CAD.Further studies are warranted to confirm our results and to elucidate the specific pathogenic mechanisms. |
| Databáze: | OpenAIRE |
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