Muscle Atrophy, Voluntary Activation Disturbances, and Low Serum Concentrations of IGF-1 and IGFBP-3 Are Associated With Weakness in People With Chronic Stroke
| Autor: | Ana Beatriz Oliveira, Thiago Luiz Russo, Araci Teixeira Guimarães, Christiane L. Prado-Medeiros, Tania F. Salvini, Carolina Carmona Alcântara, Marcela A. Silva-Couto, Rosana Mattioli |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Muscle Strength Dynamometer Weakness Vastus medialis Physical Therapy Sports Therapy and Rehabilitation Walking Electromyography Quadriceps Muscle Physical medicine and rehabilitation Internal medicine medicine Humans Knee Muscle Strength Insulin-Like Growth Factor I Postural Balance Aged medicine.diagnostic_test business.industry Muscle weakness Skeletal muscle Middle Aged Magnetic Resonance Imaging Muscle atrophy Paresis Stroke Muscular Atrophy Cross-Sectional Studies Insulin-Like Growth Factor Binding Protein 3 Hemiparesis medicine.anatomical_structure Endocrinology Torque Case-Control Studies Quality of Life Female medicine.symptom business Biomarkers |
| Zdroj: | Physical Therapy. 94:957-967 |
| ISSN: | 1538-6724 0031-9023 |
| Popis: | BackgroundThe muscle weakness that is exhibited poststroke is due to a multifactorial etiology involving the central nervous system and skeletal muscle changes. Insulinlike growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) have been described as biomarkers of neuromuscular performance in many conditions. However, no information about these biomarkers is available for people with chronic hemiparesis.ObjectiveThe purpose of this study was to investigate possible factors involved in muscle weakness, such as IGF-1 and IGFBP-3 serum concentrations, muscle volume, and neuromuscular performance of the knee flexors and extensors, in people with chronic hemiparesis poststroke.DesignThis was a cross-sectional study.MethodsA cross-sectional study was performed on 14 individuals poststroke who were paired with healthy controls. Mobility, function, balance, and quality of life were recorded as outcome measures. Knee flexor and extensor muscle volumes and neuromuscular performance were measured using nuclear magnetic resonance imaging, dynamometry, and electromyography. The serum concentrations of IGF-1 and IGFBP-3 were quantified by enzyme-linked immunosorbent assay (ELISA).ResultsThe hemiparetic group had low serum concentrations of IGF-1 (25%) and IGFBP-3 (40%); reduced muscle volume in the vastus medialis (32%), vastus intermedius (29%), biceps femoris (16%), and semitendinosus and semimembranosus (12%) muscles; reduced peak torque, power, and work of the knee flexors and extensors; and altered agonist and antagonist muscle activation compared with controls.ConclusionsLow serum concentrations of IGF-1 and IGFBP-3, deficits in neuromuscular performance, selective muscle atrophy, and decreased agonist muscle activation were found in the group with chronic hemiparesis poststroke. Both hemorrhagic and ischemic stroke were considered, and the data reflect a chronic poststroke population with good function. |
| Databáze: | OpenAIRE |
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