A comparative study of stabilising effect and antioxidant activity of different antioxidants on levodopa-loaded liposomes
| Autor: | M.L. González-Rodríguez, María José Cózar-Bernal, Antonio Merchán Alvarez, Elena García Esteban |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Curcumin
Antioxidant medicine.medical_treatment Dopamine Agents Lipid Bilayers Pharmaceutical Science Bioengineering Ascorbic Acid 02 engineering and technology 030226 pharmacology & pharmacy Antioxidants Antiparkinson Agents Levodopa Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Colloid and Surface Chemistry Drug Stability medicine Cationic liposome Physical and Theoretical Chemistry Lipid bilayer Liposome biology Superoxide Dismutase Vesicle Organic Chemistry 021001 nanoscience & nanotechnology Ascorbic acid Drug Liberation chemistry Liposomes biology.protein 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of Microencapsulation. 35:357-371 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.1080/02652048.2018.1487473 |
| Popis: | The aim of this study was to evaluate the stability of levodopa liposomes co-loaded with three different antioxidants (curcumin, ascorbic acid, and superoxide dismutase (SOD)). For this purpose, multilamellar liposomes were prepared. Curcumin was added into the lipid bilayer while ascorbic acid and SOD were placed into the aqueous phase. The influence of preparation technique and surface charge were also investigated. Vesicles were characterised and free radical scavenging potential was determined. From stability study, ascorbic acid showed better stabilising effect. These co-loaded liposomes also exhibited potential radical scavenging activity where ascorbic acid played a key role. From the study of different preparation techniques and charge, we concluded that cationic liposomes made by Thin Layer Evaporation following extrusion offered the best physicochemical and stability properties. A dual mechanism of these liposomes implies the chemical stabilisation of levodopa (dose reduction) and the antioxidant effect, with a preventive effect on Parkinson's disease. |
| Databáze: | OpenAIRE |
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