Precision Medicine for Idiopathic Hypersomnia
| Autor: | Pauline Dodet, Smaranda Leu-Semenescu, Isabelle Arnulf |
|---|---|
| Přispěvatelé: | Centre National de Référence pour les Maladies Rares : narcolepsie, hypersomnie idiopathique et syndrome de Kleine-Levin [CHU Pitié-Salpêtrière], Service des Pathologies du sommeil [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Rok vydání: | 2022 |
| Předmět: |
Multiple Sleep Latency Test
Flumazenil Cataplexy [SDV]Life Sciences [q-bio] Excessive daytime sleepiness Modafinil Idiopathic Hypersomnia Hypnotic chemistry.chemical_compound 0302 clinical medicine Piperidines Precision Medicine medicine.diagnostic_test Wakefulness-Promoting Agents General Medicine Mazindol 3. Good health Psychiatry and Mental health Clinical Psychology Neuropsychology and Physiological Psychology Spiperone Anesthesia Female Sleep onset medicine.symptom Sodium Oxybate medicine.drug Pitolisant medicine.drug_class Polysomnography Disorders of Excessive Somnolence 03 medical and health sciences Clarithromycin mental disorders medicine Humans Wakefulness GABA Modulators Narcolepsy Orexins business.industry medicine.disease 030228 respiratory system chemistry Central Nervous System Stimulants Neurology (clinical) business Sleep 030217 neurology & neurosurgery |
| Zdroj: | Sleep Medicine Clinics Sleep Medicine Clinics, WB Saunders, 2019, 14, pp.333-350. ⟨10.1016/j.jsmc.2019.05.007⟩ |
| ISSN: | 1556-407X |
| DOI: | 10.1016/j.jsmc.2022.06.016 |
| Popis: | Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness despite normal or prolonged sleep. IH is distinguished from narcolepsy by the female predominance, severe morning inertia, continuous drowsiness (rather than sleep attacks), unrefreshing naps, absence of cataplexy, sleep onset in REM periods, and hypocretin deficiency. In IH, the multiple sleep latency test demonstrates low sensitivity, specificity, and reproducibility, compared with prolonged sleep monitoring. In some IH cases, an endogenous hypnotic peptide stimulating GABA receptors during wakefulness is suspected, which are improved by anti-GABA drugs. The benefits of modafinil, sodium oxybate, mazindol, and pitolisant were found in mostly retrospective studies. |
| Databáze: | OpenAIRE |
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