Alterations in PNA binding of keratinocytes in oral keratosis
| Autor: | Teruaki Iwahashi, Kunihisa Taniguchi, Jun Ohno, M Ehara |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Keratinocytes
Histology Neuraminidase Granular layer Filaggrin Proteins Epithelium Epitope Peanut Agglutinin chemistry.chemical_compound Intermediate Filament Proteins medicine Humans integumentary system biology Chemistry musculoskeletal neural and ocular physiology Mouth Mucosa General Medicine Molecular biology N-Acetylneuraminic Acid Staining Sialic acid Medical Laboratory Technology medicine.anatomical_structure biological sciences cardiovascular system biology.protein Mouth Neoplasms Leukoplakia Oral Antibody tissues Oral Keratosis |
| Zdroj: | Biotechnic & Histochemistry. 86:168-173 |
| ISSN: | 1473-7760 1052-0295 |
| DOI: | 10.3109/10520290903532994 |
| Popis: | Changes in the expression of peanut lectin (PNA) were examined in keratinocytes of oral keratosis showing a mixture of hyperortho- and hyperparakeratinized epithelium. In the hyperorthokeratinized epithelium, which was reacted with anti-filaggrin antibody in both granular and cornified cells, PNA bound to the surface of keratinocytes from the spinous layer to the granular layer. Neither anti-filaggrin nor PNA reactions were detected in keratinocytes of the hyperparakeratinized epithelium. After neuraminidase pretreatment, however, PNA staining appeared in all cells, except cornified cells, of both hyperortho- and hyperparakeratinized epithelia. These findings suggest that PNA-binding epitopes in keratinocytes were modified by sialic acid during the hyperparakeratotic process of oral keratosis. |
| Databáze: | OpenAIRE |
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