Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

Autor: Pierre-Henry Gabrielle, Niyazi Acar, Florian Baudin, Alassane Seydou, Alicia Chemaly, Catherine Creuzot-Garcher, Louis Arnould
Přispěvatelé: Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), An interregional grant (Programme Hospitalier de Recherche Clinique) and the Regional Council of Burgundy, by INRA, CNRS, Université de Bourgogne, Regional Council of Burgundy France (PARI Agrale 1), FEDER (European Funding for Regional Economic Development), and a French Government grant managed by the French National Research Agency (ANR) under the 'Investissements d’Avenir' program, ANR-11-LABX-0021-01-LipSTIC Labex., ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer(2011), Julien, Sabine, Laboratoires d'excellence - Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer - - Lipstic2011 - ANR-11-LABX-0021 - LABX - VALID, ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du(2011)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
genetic structures
Linoleic acid
Population
Glaucoma
Gastroenterology
elderly
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
lcsh:Ophthalmology
Internal medicine
medicine
Humans
Docosatetraenoic acid
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
education
Intraocular Pressure
Margaric Acid
Aged
chemistry.chemical_classification
Aged
80 and over
education.field_of_study
business.industry
fatty acids profile
Fatty Acids
General Medicine
medicine.disease
Eicosapentaenoic acid
eye diseases
Ophthalmology
Cross-Sectional Studies
glaucoma
Hexadecenoic Acid
chemistry
lcsh:RE1-994
population-based study
[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Montrachet study
030221 ophthalmology & optometry
Visual Field Tests
sense organs
Visual Fields
business
030217 neurology & neurosurgery
Glaucoma
Open-Angle
Polyunsaturated fatty acid
Research Article
Zdroj: BMC Ophthalmology
BMC Ophthalmology, 2021, 21 (1), pp.146. ⟨10.1186/s12886-021-01910-w⟩
BMC Ophthalmology, BioMed Central, 2021, 21 (1), pp.146. ⟨10.1186/s12886-021-01910-w⟩
BMC Ophthalmology, Vol 21, Iss 1, Pp 1-9 (2021)
ISSN: 1471-2415
DOI: 10.1186/s12886-021-01910-w⟩
Popis: Background To compare plasma fatty acids (FAs) between participants with primary open-angle glaucoma (POAG) and participants without neuropathy in an elderly population and to investigate specific FAs pattern in POAG. Methods We conducted a population-based study in participants older than 75 years. Participants underwent a comprehensive eye examination with optic nerve photographs, visual field test and optic nerve OCT with RNFL thickness measurement. Glaucomatous status was defined according to the International Society for Epidemiologic and Geographical Ophthalmology classification. Lipids were extracted from plasma and FAs methylesters prepared and analyzed by gas chromatography-mass spectrometry. Results Among the 1153 participants of the Montrachet study 810 were retained for analysis and 68 had POAG. The mean age was 82.11 ± 3.67. In multivariable analysis FAs levels were not different between POAG participants and controls (P = 0.078). A FAs pattern characterized by high negative weight of gamma-linoleic acid, eicosapentaenoic acid polyunsaturated FAs (PUFAs), Cis-7 hexadecenoic acid monounsaturated FAs (MUFAs) and high positive weight of eicosadienoic acid, docosatetraenoic acid, docosapentaenoic n-6, alpha linoleic acid PUFAs, eicosenoic acid MUFAs, margaric acid and behenic acid saturated FAs was positively associated with POAG. After adjustment for major confounders, individuals in the upper tertile of FAs pattern scores compared with those in the lower tertile were more likely to present POAG (OR = 3.09 [95% CI 1.29–7.40] P = 0.013). Conclusions We found no significant difference regarding isolated plasma FAs between participants with POAG and participants without neuropathy in elderly but specific FAs pattern might be associated with POAG.
Databáze: OpenAIRE
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