Prognostic Factors, Treatment and Outcome in a Turkish Population with Endometrial Stromal Sarcoma
| Autor: | Cenk Nayki, Yusuf Yildirim, Ayla Donertas, Emre Gultekin, Umit Nayki, Pasa Ulug |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Turkey Epidemiology Sarcoma Endometrial Stromal medicine.medical_treatment Hysterectomy Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Survival rate Neoplasm Staging Retrospective Studies Endometrial stromal sarcoma business.industry Public Health Environmental and Occupational Health Retrospective cohort study Middle Aged Prognosis medicine.disease Combined Modality Therapy Comorbidity Endometrial Neoplasms Survival Rate Radiation therapy Chemotherapy Adjuvant Female Radiotherapy Adjuvant Sarcoma Neoplasm Grading Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:881-887 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2015.16.3.881 |
| Popis: | Purpose To analyze treatment modalities and prognostic factors in patients with Stage I-II endometrial stromal sarcoma (ESS). Materials and methods Twenty four patients (nineteen with low-grade ESS [LGESS] and five with high-grade ESS [HGESS]) were assessed retrospectively in terms of general characteristics, prognostic factors, treatment methods and survival. Results Twenty patients were at Stage I and three were at Stage II. The stage of one patient could not be determined. With respect to age and comorbidity, no statistically significant difference was found among disease-free survival (DFS) (p=0.990; p=0.995). However, DFS was significantly shorter in Stage II than Stage I patients (p=0.002). It was also significantly shorter in HGESS patients than in LGESS patients (p=0.000). There was no statistically significant differences among the overall survival (OVS) times of patients with respect to age at diagnosis and comorbid disease (p=0.905; p=0.979) but OVS was significantly shorter in patients with HGESS (p=0.00) and Stage II disease (p=0.001). No statistically significant difference was found with respect to OVS between patients who received radiotherapy (RT) and those who did not receive RT (p=0.055). It was not statistically possible to include other treatment modalities in the analysis because of the small sample size. Conclusions Grade and stage of a tumour were found to be the most important prognostic factors. It was not possible to determine the optimal surgical method and the effect of adjuvant treatment since the number of cases was insufficient. |
| Databáze: | OpenAIRE |
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