Persistent Markers of Kidney Injury in Children Who Developed Acute Kidney Injury After Pediatric Cardiac Surgery: A Prospective Cohort Study
| Autor: | Jef Van den Eynde, Thomas Salaets, Jacoba J. Louw, Jean Herman, Luc Breysem, Dirk Vlasselaers, Lars Desmet, Bart Meyns, Werner Budts, Marc Gewillig, Djalila Mekahli |
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| Přispěvatelé: | Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9), RS: FHML non-thematic output |
| Rok vydání: | 2022 |
| Předmět: |
Chronic/complications
Adolescent Renal Insufficiency Chronic/complications Acute Kidney Injury/diagnosis CHILDHOOD BLOOD-PRESSURE urologic and male genital diseases Kidney long‐term outcomes children Risk Factors YOUNG-ADULTS MANAGEMENT Humans Renal Insufficiency Prospective Studies Cardiac Surgical Procedures Renal Insufficiency Chronic Child POPULATION Retrospective Studies OUTCOMES urogenital system MORTALITY Acute Kidney Injury congenital heart disease female genital diseases and pregnancy complications DYSFUNCTION Cardiac Surgical Procedures/adverse effects PREVALENCE CONGENITAL HEART-DISEASE acute kidney injury Cardiology and Cardiovascular Medicine chronic kidney disease cardiac surgery long-term outcomes Glomerular Filtration Rate |
| Zdroj: | Journal of the American Heart Association, 11(7):024266. Wiley |
| ISSN: | 2047-9980 |
| Popis: | Background Acute kidney injury (AKI) after pediatric cardiac surgery is common. Longer‐term outcomes and the incidence of chronic kidney disease after AKI are not well‐known. Methods and Results All eligible children (aged 1 ‐microglobulin, blood pressure, and kidney ultrasound. Longer‐term follow‐up data on kidney function were collected at the latest available visit. Among 571 patients who underwent surgery, AKI occurred in 113 (19.7%) over a 4‐year period. Fifteen of these (13.3%) died at a median of 31 days (interquartile range [IQR], 9–57) after surgery. A total of 66 patients participated in the kidney assessment at a median of 4.8 years (IQR, 3.9–5.7) after the index AKI episode. Thirty‐nine patients (59.1%) had at least 1 marker of kidney injury, including estimated glomerular filtration rate 2 in 9 (13.6%), proteinuria in 27 (40.9%), α 1 ‐microglobinuria in 5 (7.6%), hypertension in 13 (19.7%), and abnormalities on kidney ultrasound in 9 (13.6%). Stages 1 to 5 chronic kidney disease were present in 18 (27.3%) patients. Patients with CKD were more likely to have an associated syndrome (55.6% versus 20.8%, P =0.015). At 13.1 years (IQR, 11.2–14.0) follow‐up, estimated glomerular filtration rate Conclusions Children who developed AKI after pediatric cardiac surgery showed persistent markers of kidney injury. As chronic kidney disease is a risk factor for cardiovascular comorbidity, long‐term kidney follow‐up in this population is warranted. |
| Databáze: | OpenAIRE |
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