Relationships of Measured and Genetically Determined Height With the Cardiac Conduction System in Healthy Adults
| Autor: | Sébastien Thériault, Stefanie Aeschbacher, David Conen, Martin Risch, Guillaume Paré, Christine M. Albert, Lorenz Risch, Steffen Blum, Matthias Bossard, Selina Bernet, Thomas Kofler, Philipp Krisai |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty 030204 cardiovascular system & hematology Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Conduction System Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Epidemiology Statistics Heart rate medicine Humans 030212 general & internal medicine Risk factor 610 Medicine & health medicine.diagnostic_test business.industry Atrial fibrillation medicine.disease Body Height Cardiology Female Electrical conduction system of the heart Cardiology and Cardiovascular Medicine business |
| Zdroj: | ResearcherID Circulation. Arrhythmia and electrophysiology |
| DOI: | 10.7892/boris.112502 |
| Popis: | Background— Increasing height is an independent risk factor for atrial fibrillation, but the underlying mechanisms are unknown. We hypothesized that height-related differences in electric conduction could be potential mediators of this relationship. Methods and Results— We enrolled 2149 adults aged 25 to 41 years from the general population. Height was directly measured, and a resting 12-lead ECG obtained under standardized conditions. Multivariable linear regression models were used to evaluate the association between measured height and ECG parameters. Mendelian randomization analyses were then performed using 655 independent height-associated genetic variants previously identified in the GIANT consortium. Median age was 37 years, and median height was 1.71 m. Median PR interval, QRS duration, and QTc interval were 156, 88, and 402 ms, respectively. After multivariable adjustment, β-coefficients (95% confidence intervals) per 10 cm increase in measured height were 4.17 (2.65–5.69; P P P =0.02) in PR interval and 2.57 ms (1.33–3.83; P Conclusions— In this large population-based study, we found significant associations of measured and genetically determined height with PR interval and QRS duration. Our findings suggest that adult height is a marker of altered cardiac conduction and that these relationships may be causal. |
| Databáze: | OpenAIRE |
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