Sex differences in continuous-flow ventricular assist device therapy for advanced heart failure
| Autor: | Satsuki Fukushima, Junjiro Kobayashi, Yorihiko Matsumoto, Yusuke Shimahara, Naoki Tadokoro, Takashi Kakuta, Tomoyuki Fujita |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Surgical oncology parasitic diseases Female patient Humans Medicine cardiovascular diseases 030212 general & internal medicine Retrospective Studies Heart Failure Sex Characteristics business.industry Continuous flow Incidence (epidemiology) General Medicine medicine.disease Cardiac surgery Surgery Treatment Outcome Cardiothoracic surgery Heart failure Ventricular assist device Heart Transplantation Female Heart-Assist Devices biological phenomena cell phenomena and immunity Cardiology and Cardiovascular Medicine business |
| Zdroj: | General Thoracic and Cardiovascular Surgery. 69:919-925 |
| ISSN: | 1863-6713 1863-6705 |
| Popis: | The effect of patient sex in continuous-flow ventricular assist device (c-VAD) therapy has not been well described. We investigated sex-specific differences in clinical outcomes related to c-VAD therapy for Japanese patients.We retrospectively analyzed 153 patients, including 41 (27%) female patients who underwent c-VAD implantation over the last 13 years in our institution for a mean follow-up of 766 ± 446 days. Clinical outcomes were compared between male and female patients RESULTS: There was no significant difference in mortality, cerebral vascular accidents, the severity of heart failure, or driveline infection in patients who underwent c-VAD implantation, regardless of sex. While male patients tended to have more bleeding at the time of surgery, female patients had significantly higher rates of non-surgical bleeding during subsequent c-VAD therapy, mainly from gynecological origins.Female patients treated with c-VAD had a significantly higher incidence of non-surgical bleeding events. Careful attention to gynecological complications and sex-specific care is required in female patients with c-VAD. |
| Databáze: | OpenAIRE |
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