The Role of Diffusion-Weighted MRI and Apparent Diffusion Coefficient in Assessment of Diabetic Kidney Disease: Preliminary Experience Study
| Autor: | Nasr Mohamed M. Osman, Taghreed A E L Aziz Nasr, Moustafa Abdel Kader, Hesham Kamal Habeeb Keryakos, Mohamed Ahmed Sharawy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
ADC value International Journal of Nephrology and Renovascular Disease 030232 urology & nephrology Urology Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine DW-MRI Parenchyma medicine Renal fibrosis Effective diffusion coefficient Stage (cooking) Original Research Kidney business.industry medicine.disease diabetic kidney disease body regions medicine.anatomical_structure Nephrology business Kidney disease Diffusion MRI |
| Zdroj: | International Journal of Nephrology and Renovascular Disease |
| ISSN: | 1178-7058 |
| Popis: | Nasr Mohamed Mohamed Osman,1 Moustafa Abdel Kader,1 Taghreed A EL Aziz Nasr,1 Mohamed Ahmed Sharawy,2 Hesham Kamal Habeeb Keryakos2 1Radiology Department, Faculty of Medicine, Minia University, El Minia, Egypt; 2Internal Medicine Department, Faculty of Medicine, Minia University, El Minia, EgyptCorrespondence: Moustafa Abdel KaderRadiology Department, Minia University Hospital, Minia Faculty of Medicine, Aswan-Cairo Agricultural Road, El-Minia 61111, EgyptTel +20-1027307617Email Moustafa18_1970@yahoo.comBackground: Diabetic kidney disease is the most common cause of ESRD. There is poor correlation between the degree of renal fibrosis and current screening markers. A noninvasive imaging technique is needed to assess the degree of structural changes in the kidney. The aim of this study was to assess the role of apparent diffusion coefficient (ADC) in the diagnosis of diabetic kidney disease. Forty adult diabetic patients with chronic kidney disease as well as 20 age- and sex-matched adult healthy controls were recruited from Nephrology Department of our University Hospital. All patients underwent renal MR-DWI and ADC mapping on a 1.5-T scanner (Philips Achieva) using phased array body coil.Results: Among the studied 40 diabetic patients, five groups of patients were resulted 8 patients for each and the ADC values were inversely correlated with advancement in renal parenchymal affection, ie, in late stages of the disease the ADC values were lower than in early stages. The mean ADC values of renal parenchyma in patients with diabetic kidney disease were considerably lower than that of healthy controls with normal renal function (2.1± 0.3x10− 3 mm2/s vs 2.4± 0.1x10− 3 mm2/s with p< 0.001).Conclusion: ADC value is a possible noninvasive technique in evaluating the stage of renal dysfunction with assessment of disease progression.Keywords: diabetic kidney disease, DW-MRI, ADC value |
| Databáze: | OpenAIRE |
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