Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients

Autor: Bruce H. R. Wolffenbuttel, Paul J.M.R. Lemmens, G. J. W. M. Rondas-Colbers, W.A. Oranje, J. P. J. E. Sels
Přispěvatelé: Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CARIM School for Cardiovascular Diseases
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Zdroj: Clinica Chimica Acta, 311(2), 91-94. Elsevier
ISSN: 0009-8981
Popis: Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients.Oranje WA, Sels JP, Rondas-Colbers GJ, Lemmens PJ, Wolffenbuttel BH.Department of Endocrinology and Metabolism, University Hospital Maastricht, Maastricht, The Netherlands. Oranje@rdgg.nlBACKGROUND: Oxidative stress in diabetes increases lipid peroxidation, which stimulates the development of atherosclerosis. METHODS: We investigated in a 3-month placebo-controlled study with 19 normocholesterolemic type 2 diabetic patients whether treatment with 10-mg atorvastatin influenced antioxidants and reduced LDL oxidizability, assessed by in vitro production of conjugated dienes after copper-induced LDL oxidation. RESULTS: The lag phase, as a measure of the resistance of LDL to oxidation, did not change (62.8+/-8.2 respectively 59.6+/-9.7 min, p=n.s.), while conjugated dienes decreased (512+/-74 respectively 487+/-50 nmol, p=0.012). Plasma alpha-tocopherol and ubiquinol levels decreased, while their ratios to LDL cholesterol remained stable. CONCLUSIONS: Atorvastatin favourably influences some parameters of LDL oxidation. Whether this effect is clinically relevant remains to be determined.
Databáze: OpenAIRE