Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients
Autor: | Bruce H. R. Wolffenbuttel, Paul J.M.R. Lemmens, G. J. W. M. Rondas-Colbers, W.A. Oranje, J. P. J. E. Sels |
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Přispěvatelé: | Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CARIM School for Cardiovascular Diseases |
Jazyk: | angličtina |
Rok vydání: | 2001 |
Předmět: |
Blood Glucose
Male medicine.medical_specialty Ubiquinol Antioxidant Ubiquinone Atorvastatin medicine.medical_treatment Clinical Biochemistry Type 2 diabetes medicine.disease_cause Biochemistry Antioxidants Lipid peroxidation chemistry.chemical_compound Double-Blind Method Internal medicine Diabetes mellitus medicine Humans Vitamin E Pyrroles Aged Glycated Hemoglobin Vascular disease Anticholesteremic Agents Biochemistry (medical) Cholesterol LDL General Medicine Middle Aged medicine.disease Lipids Endocrinology Diabetes Mellitus Type 2 chemistry Heptanoic Acids Female lipids (amino acids peptides and proteins) Oxidation-Reduction Oxidative stress medicine.drug |
Zdroj: | Clinica Chimica Acta, 311(2), 91-94. Elsevier |
ISSN: | 0009-8981 |
Popis: | Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients.Oranje WA, Sels JP, Rondas-Colbers GJ, Lemmens PJ, Wolffenbuttel BH.Department of Endocrinology and Metabolism, University Hospital Maastricht, Maastricht, The Netherlands. Oranje@rdgg.nlBACKGROUND: Oxidative stress in diabetes increases lipid peroxidation, which stimulates the development of atherosclerosis. METHODS: We investigated in a 3-month placebo-controlled study with 19 normocholesterolemic type 2 diabetic patients whether treatment with 10-mg atorvastatin influenced antioxidants and reduced LDL oxidizability, assessed by in vitro production of conjugated dienes after copper-induced LDL oxidation. RESULTS: The lag phase, as a measure of the resistance of LDL to oxidation, did not change (62.8+/-8.2 respectively 59.6+/-9.7 min, p=n.s.), while conjugated dienes decreased (512+/-74 respectively 487+/-50 nmol, p=0.012). Plasma alpha-tocopherol and ubiquinol levels decreased, while their ratios to LDL cholesterol remained stable. CONCLUSIONS: Atorvastatin favourably influences some parameters of LDL oxidation. Whether this effect is clinically relevant remains to be determined. |
Databáze: | OpenAIRE |
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