Radiotherapy in prostate cancer after kidney transplant in 6 cases
| Autor: | G. Stocchi, V. Maragna, Giulio Francolini, M.A. Teriaca, M. Mariotti, Beatrice Detti, Andrea Gaetano Allegra, Manuele Roghi, Angela Sardaro, Lorenzo Livi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Brachytherapy Population 030232 urology & nephrology Dose constraints Kidney transplant 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Internal medicine medicine Humans education education.field_of_study business.industry Incidence Incidence (epidemiology) Prostatic Neoplasms Cancer General Medicine medicine.disease Kidney Transplantation Transplant Recipients Radiation therapy medicine.anatomical_structure 030220 oncology & carcinogenesis business |
| Zdroj: | Tumori Journal. 108:371-375 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/03008916211013914 |
| Popis: | Background: Patients who received a kidney transplant (KT) are described in literature as a group with a higher incidence of malignant neoplasms compared to the general population. Cancer development after KT has become a major issue, as a remarkable percentage of patients are diagnosed with cancer. Treatment of prostate cancer (PCa) in renal transplant recipients (RTRs) is a challenging issue that has been discussed by many authors over the years, but evidence is sparse and often includes conflicting reports. Among the therapeutic options for PCa in these patients, prostate irradiation represents a valuable alternative to surgery or other systemic therapies, as RTRs are often ineligible for these treatments. Objective: To report six cases treated at our institution between 1998 and 2017 and discuss the available literature. Methods: Patients’ characteristics were reported along with biochemical status at diagnosis, type of immunosuppressive treatment, radiation therapy technique, and dose to transplanted kidney. Results: Overall, prostate irradiation was delivered respecting the dose constraints and patients showed good tolerance with no reports of acute or late transplanted kidney injury. Conclusions: Our experience confirms that prostate radiotherapy for RTRs is feasible and effective and represents a valid option that should be considered by the multidisciplinary team. |
| Databáze: | OpenAIRE |
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