The non-specific antiviral activity of polysulfates to fight SARS-CoV-2, its mutants and viruses with cationic spikes
Autor: | Michel Vert |
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Rok vydání: | 2021 |
Předmět: |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
0206 medical engineering Mutant Biomedical Engineering Biophysics Air Microbiology Bioengineering 02 engineering and technology Antiviral Agents Virus Biomaterials Non specific Viral envelope In vivo Humans Chemistry SARS-CoV-2 Sulfates Nebulizers and Vaporizers Cationic polymerization COVID-19 021001 nanoscience & nanotechnology 020601 biomedical engineering Virology Polyelectrolytes In vitro COVID-19 Drug Treatment Oral Sprays 0210 nano-technology |
Zdroj: | Journal of biomaterials science. Polymer edition. 32(11) |
ISSN: | 1568-5624 |
Popis: | Polyanions are negatively charged macromolecules known for several decades as inhibitors of many viruses in vitro, notably AIDS virus. In the case of enveloped viruses, this activity was assigned to the formation of a polyelectrolyte complex between an anionic species, the polyanion, and the spike cationic proteins which are, for polymer chemists, comparable to cationic polyelectrolytes. Unfortunately, in vitro antiviral activity was not confirmed in vivo, possibly because polyanions were captured by cationic blood elements before reaching target cells. Accordingly, virologists abandoned the use of polyanions for antiviral therapy. In the case of coronaviruses like SARS-CoV-2 and its mutants the game may not be over because these viruses infect cells of airways and not of blood. This communication proposes strategies to use polysulfates to attack and inhibit viral particles before they reach target cells in the airways. For this, polysulfate solutions may be administered by spray, gargling and nebulization or used to capture virus-containing droplets and aerosols by bubbling when these vectors are in the atmosphere. The technical means exist. However, biocompatibility and biofunctionality tests are necessary in the case of airways. Such tests require manipulation of pathogens, something which is beyond the competences of a biomaterialist. For this, a specialist in virology is necessary. Attempts to find one failed so far despite all-around solicitations over the past ten months and despite the fact that attacking the virus with polysulfates may complement beneficially the defensive strategies based on masks, vaccines and hospitals. |
Databáze: | OpenAIRE |
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