Elevation of ventricular defibrillation threshold in dogs by antiarrhythmic drugs
| Autor: | S J Whistler, Leslie A. Geddes, Willis A. Tacker, Charles F. Babbs, Gkw Yim |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Resuscitation ACLS Defibrillation medicine.medical_treatment resuscitation Blood Pressure cardiac arrest Defibrillation threshold Dogs Bolus (medicine) Internal medicine medicine Animals fibrillation Biomedical Engineering and Bioengineering Fibrillation Intravenous drug business.industry Advanced cardiac life support Lidocaine Peak current Quinidine Phenytoin Anesthesia Ventricular Fibrillation Cardiology advanced cardiac life support medicine.symptom Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents |
| Zdroj: | Weldon School of Biomedical Engineering Faculty Publications |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(79)90047-4 |
| Popis: | Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhythmic drugs tested. Bolus injections produced a transient rise, and continuous infusions produced a steady rise in defibrillation threshold. The maximal percent elevations in mean defibrillation threshold during the 60 minutes after intravenous drug treatment in groups of n = 5 dogs were: Treatment % increase in TDE % increase in TPC Lidocaine bolus (3 mg/kg) 48 26 Lidocaine (0.5 mg/Kg/min) 99 45 Quinidine bolus (50 mg/Kg) 172 70 Diphenylhydantoin (1 mg/Kg/min) 83 35 Controls 1 4 Accordingly, individuals receiving antiarrhythmic drugs whose hearts nonetheless fibrillate may require greater electric shock strength for defibrillation. |
| Databáze: | OpenAIRE |
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