T lymphocytes, monocytes and erythropoiesis disorders in chronic renal failure
| Autor: | Silvia Carozzi, Silvano Lamperi |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Erythroid progenitor T-Lymphocytes chemical and pharmacologic phenomena Cell Separation Monocytes Colony-Forming Units Assay Peritoneal Dialysis Continuous Ambulatory Renal anemia Renal Dialysis hemic and lymphatic diseases Medicine Humans Erythropoiesis Cells Cultured business.industry Macrophages Antibodies Monoclonal hemic and immune systems Middle Aged Hematopoietic Stem Cells medicine.anatomical_structure Immunology Chronic renal failure Interleukin-2 Kidney Failure Chronic Female Bone marrow business Lymphocytes+Monocytes circulatory and respiratory physiology |
| Zdroj: | Nephron. 39(3) |
| ISSN: | 1660-8151 |
| Popis: | The T lymphocytes, OKT4-depleted T lymphocytes, monocytes, macrophages and the bone marrow early erythroid progenitor (BFU-E) interactions have been evaluated in normal subjects and in uremic patients in predialysis phase (PDP), on hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). In the same subjects the T-cell growth factor (TCGF) activity and the T-cell subset identification have also been assessed. The results show in uremic patients, particularly in the presence of reduced OKT4 subset and TCGF activity, a blockage of the interactions between immunocompetent and bone marrow cells which normally could stimulate early erythroid progenitor growth. Since this blockage is partially removed by CAPD, this may suggest a more efficient removal of an interaction inhibitor with CAPD than with other dialysis techniques. The mechanism by which such a material may act appears unclear, but it is possible to suppose an inhibiting activity on the production of TCGF by lympho-monocyte cells which under normal conditions could be considered as an early erythropoiesis regulatory factor. |
| Databáze: | OpenAIRE |
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