Phasic Off responses of auditory cortex underlie perception of sound duration
| Autor: | Huizhong W. Tao, Dijia Wang, Jinfeng Xu, Jian Wang, Li I. Zhang, Guilong Liu, Feixue Liang, Changbao Song, Weilong Huang, Haifu Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Auditory perception Parallel processing (psychology) Male Patch-Clamp Techniques QH301-705.5 media_common.quotation_subject Action Potentials Gene Expression Mice Transgenic Inhibitory postsynaptic potential Auditory cortex General Biochemistry Genetics and Molecular Biology Article sound duration encoding 03 medical and health sciences synaptic mechanisms phantom sound Mice 0302 clinical medicine Bacterial Proteins Genes Reporter Perception Animals sound duration detection Biology (General) Wakefulness media_common Sound (medical instrument) Auditory Cortex biology Pyramidal Cells Electrodes Implanted Off response Mice Inbred C57BL Optogenetics Luminescent Proteins 030104 developmental biology Sound Acoustic Stimulation Duration (music) Pattern Recognition Physiological biology.protein Auditory Perception Evoked Potentials Auditory Female Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Cell Rep Cell Reports, Vol 35, Iss 3, Pp 109003-(2021) |
| Popis: | Summary: It has been proposed that sound information is separately streamed into onset and offset pathways for parallel processing. However, how offset responses contribute to auditory perception remains unclear. Here, loose-patch and whole-cell recordings in awake mouse primary auditory cortex (A1) reveal that a subset of pyramidal neurons exhibit a transient “Off” response, with its onset tightly time-locked to the sound termination and its frequency tuning similar to that of the transient “On” response. Both responses are characterized by excitation briefly followed by inhibition, with the latter mediated by parvalbumin (PV) inhibitory neurons. Optogenetically manipulating sound-evoked A1 responses at different temporal phases or artificially creating phantom sounds in A1 further reveals that the A1 phasic On and Off responses are critical for perceptual discrimination of sound duration. Our results suggest that perception of sound duration is dependent on precisely encoding its onset and offset timings by phasic On and Off responses. |
| Databáze: | OpenAIRE |
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