A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective
| Autor: | Saiful Izwan Abd Razak, Mohammed Ahmad Wsoo, Shafinaz Shahir, Siti Pauliena Mohd Bohari, Nadirul Hasraf Mat Nayan |
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| Rok vydání: | 2020 |
| Předmět: |
Chemical structure
Anti-Inflammatory Agents Nanofibers Antineoplastic Agents Cellulase 010402 general chemistry 01 natural sciences Biochemistry Antioxidants Analytical Chemistry chemistry.chemical_compound Drug Delivery Systems Anti-Infective Agents Animals Humans Amino Acids Cellulose biology 010405 organic chemistry Chemistry Organic Chemistry Biomaterial Vitamins General Medicine Biodegradation Cellulose acetate Electrospinning 0104 chemical sciences Chemical engineering Nanofiber Drug delivery biology.protein |
| Zdroj: | Carbohydrate Research. 491:107978 |
| ISSN: | 0008-6215 |
| Popis: | Cellulose acetate (CA) is a remarkable biomaterial most extensively used in biomedical applications due to their properties. This review highlighted the synthesis and chemical structure of CA polymer as well as focused on the mechanical, chemical, thermal, biocompatible, and biodegradable properties of electrospun CA nanofibers. These properties are essential in the evaluation of the CA nanofibers and provide information as a reference for the further utilization and improvement of CA nanofibers. Moreover, we have summarized the use of electrospun CA nanofibers in the drug delivery system as a carrier for drugs and classify them according to the drug class, including anti-inflammatory, anticancer, antioxidant, antimicrobial agents, vitamins and amino acids. Our review has been concluded that CA nanofibers cannot wholly be biodegraded within the human body due to the absence of cellulase enzyme but degraded by microorganisms. Hence, the biodegradation of CA nanofibers in vivo has addressed as a critical challenge. |
| Databáze: | OpenAIRE |
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