Combined intensive chemoradiotherapy for organ preservation in patients with resectable and non-resectable oesophageal cancer
| Autor: | R. Kneitschel, E. Aman, C. Blajman, A. Fiorini, C. Milano, S. Carraro, A. Jarentchuk, M. Barugel, J. Nadal, E. Roca, G. Gonzalez, R. Giglio, M. Sardi, E. Pennella, M.T. Santarelli, A. Navigante |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Leucovorin Mitomycins Bleomycin Antineoplastic Combined Chemotherapy Protocols medicine Humans Combined Modality Therapy Aged Aged 80 and over Cisplatin Chemotherapy Radiotherapy business.industry Carcinoma Remission Induction Mitomycin C Induction chemotherapy Middle Aged Survival Analysis Surgery Radiation therapy Oncology Fluorouracil Disease Progression Female business Chemoradiotherapy medicine.drug |
| Zdroj: | European Journal of Cancer. 32:429-432 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/0959-8049(95)00524-2 |
| Popis: | From January 1990 to April 1993, 60 oesophageal cancer patients were enrolled in a protocol of non-surgical treatment that consisted of induction chemotherapy followed by concurrent chemoradiotherapy. Induction chemotherapy consisted of cisplatin 40 mg/m2 intravenous bolus days 1, 2, 14, 15; 24 h continuous infusion of 5-fluorouracil (5-FU) 1000 mg/m2 days 1 and 14; leucovorin 20 mg/m2 days 1 and 14 given before and with 5-FU; bleomycin 30 UI days 1 and 14; mitomycin C 10 mg/m2 day 14. Concurrent chemoradiotherapy consisted of 60 Gy (6 weeks) from day 21 and cisplatin 70 mg/m2 days 28, 42 and 56; leucovorin 20 mg/m2 followed by 5-FU 425 mg/m2 days 28, 35, 42, 49 and 56. Complete response occurred in 44 of 55 evaluable patients (80%). The median survival is 32 months; the actuarial survival at 40 months is 35% (CI 18-53). These results appear improved over those reported with surgery or radiation alone, and suggest that organ preservation as a secondary treatment goal should be vigorously investigated. |
| Databáze: | OpenAIRE |
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