Use of inhaled corticosteroids for the prevention and/or treatment of bronchopulmonary dysplasia in preterm infants: a systematic review protocol
| Autor: | Dirk Bassler, Tanja Karen, Eric S. Shinwell, Igor Portnov, Joerg J Meerpohl |
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| Přispěvatelé: | University of Zurich, Bassler, Dirk |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Research design
Pediatrics medicine.medical_specialty Medicine (miscellaneous) 610 Medicine & health Inhaled corticosteroids law.invention Randomized controlled trial law Adrenal Cortex Hormones Administration Inhalation Protocol Medicine Corticosteroids Humans Intensive care medicine Randomized Controlled Trials as Topic Protocol (science) business.industry Potential risk Prevention Postmenstrual Age Infant Newborn 2701 Medicine (miscellaneous) 10027 Clinic for Neonatology medicine.disease Bronchopulmonary dysplasia Quality of evidence Research Design Preterm infant business Infant Premature Systematic Reviews as Topic |
| Zdroj: | Systematic Reviews |
| ISSN: | 2046-4053 |
| Popis: | Background Inhaled steroids have been studied for both prevention and treatment of bronchopulmonary dysplasia (BPD). Results have been inconsistent. Recently, a large randomized controlled trial (RCT) has been reported. Methods/design We will perform a comprehensive systematic literature search for randomized and quasi-randomized controlled trials that studied the efficacy and safety of inhaled corticosteroids administered to preterm infants (22–36 weeks) for either the prevention or treatment of BPD diagnosed by both clinical and physiological outcome criteria. We will assess potential risk of bias for each RCT meeting our selection criteria using the Cochrane risk of bias tool for RCTs. The primary outcome of interest will be mortality or BPD or both at 28 days postnatal age or 36 weeks postmenstrual age. Pooled estimates will be calculated using RevMan software with a random effects model as primary analysis. We will assess the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Discussion Meta-analytic estimates of eligible RCTs, potentially including a new large RCT, may significantly influence neonatal practice in the prevention and treatment of respiratory problems in preterm infants. Systematic review registration PROSPEROCRD42015019628 |
| Databáze: | OpenAIRE |
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